Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 715918..716494 Replicon chromosome
Accession NZ_CP087803
Organism Moraxella bovis strain SAM57947

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP097_RS03755 Protein ID WP_228157854.1
Coordinates 716234..716494 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP097_RS03750 Protein ID WP_078273964.1
Coordinates 715918..716253 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP097_RS03730 (LP097_03700) 711077..712159 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP097_RS03735 (LP097_03705) 712293..713060 - 768 WP_112742541.1 carbonic anhydrase family protein -
LP097_RS03740 (LP097_03710) 713706..714887 - 1182 WP_078274027.1 fatty acid desaturase -
LP097_RS03745 (LP097_03715) 715150..715734 + 585 Protein_724 TetR/AcrR family transcriptional regulator -
LP097_RS03750 (LP097_03720) 715918..716253 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP097_RS03755 (LP097_03725) 716234..716494 - 261 WP_228157854.1 type II toxin-antitoxin system HicA family toxin Toxin
LP097_RS03760 (LP097_03730) 716693..717400 + 708 WP_078273965.1 ParA family protein -
LP097_RS03765 (LP097_03735) 717490..718875 - 1386 WP_078273966.1 APC family permease -
LP097_RS03770 (LP097_03740) 719388..721463 - 2076 WP_112742539.1 NAD-dependent DNA ligase LigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9574.50 Da        Isoelectric Point: 4.4681

>T226204 WP_228157854.1 NZ_CP087803:c716494-716234 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHHDN

Download         Length: 261 bp

>T226204 NZ_CP122318:1322539-1323861 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226204 WP_078273964.1 NZ_CP087803:c716253-715918 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226204 NZ_CP122318:1322273-1322539 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References