Detailed information of TA system TA226202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 466843..467401
• Replicon: chromosome
• Accession: NZ_CP087803
• Organism: Moraxella bovis strain SAM57947

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP097_RS02450
• Protein ID: WP_228157760.1
• Coordinates: 467129..467401 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP097_RS02445
• Protein ID: WP_264688802.1
• Coordinates: 466843..467136 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP097_RS02415 (LP097_02400)	462549..463883	-	1335	WP_264688799.1	valine--pyruvate transaminase	-
LP097_RS02420 (LP097_02405)	464003..464614	+	612	WP_115368690.1	methyltransferase	-
LP097_RS02425 (LP097_02410)	464721..465071	+	351	WP_181879486.1	PIN domain protein	-
LP097_RS02430 (LP097_02415)	465061..465264	+	204	WP_115368689.1	hypothetical protein	-
LP097_RS02435 (LP097_02420)	465384..466457	+	1074	WP_264688800.1	dNTP triphosphohydrolase	-
LP097_RS02440 (LP097_02425)	466484..466699	+	216	WP_264688801.1	hypothetical protein	-
LP097_RS02445 (LP097_02430)	466843..467136	+	294	WP_264688802.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP097_RS02450 (LP097_02435)	467129..467401	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP097_RS02455 (LP097_02440)	467466..467921	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP097_RS02460 (LP097_02445)	467981..468250	+	270	WP_264677328.1	hypothetical protein	-
LP097_RS02465 (LP097_02450)	468247..468627	+	381	WP_264688803.1	type II toxin-antitoxin system VapC family toxin	-
LP097_RS02470 (LP097_02455)	468624..469883	+	1260	WP_264688804.1	replication-associated recombination protein A	-
LP097_RS02475 (LP097_02460)	469963..470226	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP097_RS02480 (LP097_02465)	470223..470615	+	393	WP_264677325.1	type II toxin-antitoxin system VapC family toxin	-
LP097_RS02485 (LP097_02470)	470738..471268	+	531	WP_078275187.1	HI_0552 family protein	-
LP097_RS02490 (LP097_02475)	471265..471831	-	567	WP_078275186.1	hypothetical protein	-
LP097_RS02495 (LP097_02480)	471834..472070	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	katA	417905..469883	51978

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-88)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226202 WP_228157760.1 NZ_CP087803:467129-467401 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226202 NZ_CP122318:991507-991610 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11087.36 Da
• Isoelectric Point: 4.7815

>AT226202 WP_264688802.1 NZ_CP087803:466843-467136 [Moraxella bovis]
MSRTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226202 NZ_CP122318:c991648-991377 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT