Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 25602..26231 Replicon chromosome
Accession NZ_CP087803
Organism Moraxella bovis strain SAM57947

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP097_RS00105 Protein ID WP_264688770.1
Coordinates 26040..26231 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP097_RS00100 Protein ID WP_264688769.1
Coordinates 25602..26006 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP097_RS00090 (LP097_00095) 21237..21632 - 396 WP_264676533.1 hypothetical protein -
LP097_RS00095 (LP097_00100) 21711..25526 - 3816 WP_264676534.1 phage tail tape measure protein -
LP097_RS00100 (LP097_00105) 25602..26006 - 405 WP_264688769.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP097_RS00105 (LP097_00110) 26040..26231 - 192 WP_264688770.1 type II toxin-antitoxin system HicA family toxin Toxin
LP097_RS00110 (LP097_00115) 26379..26567 - 189 WP_115008210.1 hypothetical protein -
LP097_RS00115 (LP097_00120) 26570..27286 - 717 WP_264688771.1 antA/AntB antirepressor family protein -
LP097_RS00120 (LP097_00125) 27283..27669 - 387 WP_115008209.1 hypothetical protein -
LP097_RS00125 (LP097_00130) 27786..28265 + 480 WP_264688772.1 helix-turn-helix domain containing protein -
LP097_RS00130 (LP097_00135) 28337..29086 - 750 WP_264688773.1 hypothetical protein -
LP097_RS00135 (LP097_00140) 29155..29484 - 330 WP_264688774.1 Gp49 family protein -
LP097_RS00140 (LP097_00145) 29549..30541 - 993 WP_078274947.1 major capsid protein -
LP097_RS00145 (LP097_00150) 30586..30960 - 375 WP_078274948.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 21711..64574 42863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7027.10 Da        Isoelectric Point: 11.0174

>T226200 WP_264688770.1 NZ_CP087803:c26231-26040 [Moraxella bovis]
MASSREVIKIIKADGWYRVKSNGGSHQQFKHPTKKGRVTVPHPKKDLAQPTIDSIMRQAGLSD

Download         Length: 192 bp

>T226200 NZ_CP122318:826025-826279 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15038.16 Da        Isoelectric Point: 4.7053

>AT226200 WP_264688769.1 NZ_CP087803:c26006-25602 [Moraxella bovis]
MLYPIAILKGDDKTAHGIFFPDVPNLASACDDLQDVHKMALECLDVHFSGLVEDGEEIPLPTNFDAHTQNSQFDGMMWAW
VDVDLSKYDVKSHKINITLPNYLIAKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 405 bp

>AT226200 NZ_CP122318:825777-826028 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References