Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2226034..2226692 | Replicon | chromosome |
| Accession | NZ_CP087800 | ||
| Organism | Moraxella bovis strain SAM57953 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP087_RS11305 | Protein ID | WP_078274940.1 |
| Coordinates | 2226504..2226692 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP087_RS11300 | Protein ID | WP_112741846.1 |
| Coordinates | 2226034..2226441 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP087_RS11270 (LP087_11165) | 2221047..2222942 | + | 1896 | WP_208624073.1 | ATP-dependent zinc metalloprotease FtsH | - |
| LP087_RS11275 (LP087_11170) | 2223060..2223833 | + | 774 | WP_112742782.1 | lysophospholipid acyltransferase family protein | - |
| LP087_RS11280 (LP087_11175) | 2223835..2224380 | - | 546 | WP_264717808.1 | WG repeat-containing protein | - |
| LP087_RS11285 (LP087_11180) | 2224377..2224724 | - | 348 | WP_264717809.1 | hypothetical protein | - |
| LP087_RS11290 (LP087_11185) | 2224658..2224990 | - | 333 | WP_112741848.1 | hypothetical protein | - |
| LP087_RS11295 (LP087_11190) | 2224987..2225958 | - | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP087_RS11300 (LP087_11195) | 2226034..2226441 | - | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP087_RS11305 (LP087_11200) | 2226504..2226692 | - | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP087_RS11310 (LP087_11205) | 2226835..2227050 | - | 216 | WP_078274941.1 | hypothetical protein | - |
| LP087_RS11315 (LP087_11210) | 2227052..2227651 | - | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP087_RS11320 (LP087_11215) | 2227758..2227964 | - | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP087_RS11325 (LP087_11220) | 2228087..2228431 | + | 345 | WP_078274944.1 | helix-turn-helix transcriptional regulator | - |
| LP087_RS11330 (LP087_11225) | 2228475..2229227 | - | 753 | WP_078274945.1 | hypothetical protein | - |
| LP087_RS11335 (LP087_11230) | 2229305..2229505 | - | 201 | WP_264676324.1 | hypothetical protein | - |
| LP087_RS11340 (LP087_11235) | 2229514..2229705 | - | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP087_RS11345 (LP087_11240) | 2229720..2229929 | - | 210 | WP_078274960.1 | hypothetical protein | - |
| LP087_RS11350 (LP087_11245) | 2230094..2230393 | + | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP087_RS11355 (LP087_11250) | 2230588..2230875 | + | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP087_RS11360 (LP087_11255) | 2230872..2231291 | + | 420 | WP_112741841.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2221047..2231291 | 10244 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226199 WP_078274940.1 NZ_CP087800:c2226692-2226504 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226199 NZ_CP122318:825777-826028 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226199 WP_112741846.1 NZ_CP087800:c2226441-2226034 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226199 NZ_CP122318:826025-826279 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|