Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-shpB/BrnT-BrnA
Location 1744567..1745119 Replicon chromosome
Accession NZ_CP087800
Organism Moraxella bovis strain SAM57953

Toxin (Protein)


Gene name AbkB Uniprot ID A0A1T0A7D3
Locus tag LP087_RS08660 Protein ID WP_029102268.1
Coordinates 1744567..1744845 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag LP087_RS08665 Protein ID WP_078273473.1
Coordinates 1744832..1745119 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP087_RS08630 (LP087_08545) 1740554..1741330 - 777 WP_264676230.1 nucleotidyltransferase domain-containing protein -
LP087_RS08635 (LP087_08550) 1741442..1741792 + 351 WP_078273468.1 TIGR01244 family sulfur transferase -
LP087_RS08640 (LP087_08555) 1741940..1742455 + 516 WP_115369660.1 hypothetical protein -
LP087_RS08645 (LP087_08560) 1742556..1742738 + 183 WP_264683628.1 hypothetical protein -
LP087_RS08650 (LP087_08565) 1742951..1743616 + 666 WP_078273471.1 PspA/IM30 family protein -
LP087_RS08655 (LP087_08570) 1743816..1744472 + 657 WP_078273472.1 YqiJ family protein -
LP087_RS08660 (LP087_08575) 1744567..1744845 + 279 WP_029102268.1 BrnT family toxin Toxin
LP087_RS08665 (LP087_08580) 1744832..1745119 + 288 WP_078273473.1 BrnA antitoxin family protein Antitoxin
LP087_RS08670 (LP087_08585) 1745129..1746859 + 1731 WP_078273474.1 flotillin domain-containing protein -
LP087_RS08675 1746903..1747028 - 126 WP_264676709.1 hypothetical protein -
LP087_RS08680 (LP087_08590) 1747057..1748556 - 1500 WP_112742120.1 DUF389 domain-containing protein -
LP087_RS08685 (LP087_08595) 1748635..1749684 - 1050 WP_264676228.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-85)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(36-89)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10484.81 Da        Isoelectric Point: 5.1084

>T226195 WP_029102268.1 NZ_CP087800:1744567-1744845 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Download         Length: 279 bp

>T226195 NZ_CP122317:c4551222-4551028 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10979.71 Da        Isoelectric Point: 7.0097

>AT226195 WP_078273473.1 NZ_CP087800:1744832-1745119 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Download         Length: 288 bp

>AT226195 NZ_CP122317:4550851-4551029 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T0A7D3

Antitoxin

Source ID Structure

References