Detailed information of TA system TA226193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1423372..1424029
• Replicon: chromosome
• Accession: NZ_CP087800
• Organism: Moraxella bovis strain SAM57953

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP087_RS06955
• Protein ID: WP_264676287.1
• Coordinates: 1423372..1423554 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP087_RS06960
• Protein ID: WP_264676286.1
• Coordinates: 1423616..1424029 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP087_RS06930 (LP087_06860)	1419345..1420742	-	1398	WP_264676292.1	phage terminase large subunit	-
LP087_RS06935 (LP087_06865)	1420742..1421281	-	540	WP_264676291.1	terminase small subunit	-
LP087_RS06940 (LP087_06870)	1421395..1421604	+	210	WP_264676290.1	hypothetical protein	-
LP087_RS06945 (LP087_06875)	1421641..1421841	+	201	WP_264676289.1	helix-turn-helix domain-containing protein	-
LP087_RS06950 (LP087_06880)	1422268..1422972	-	705	WP_264676288.1	BRO family protein	-
LP087_RS06955 (LP087_06885)	1423372..1423554	+	183	WP_264676287.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP087_RS06960 (LP087_06890)	1423616..1424029	+	414	WP_264676286.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP087_RS06965 (LP087_06895)	1424040..1424441	-	402	WP_264676285.1	antiterminator Q family protein	-
LP087_RS06970 (LP087_06900)	1424425..1424646	-	222	WP_264676284.1	DUF3310 domain-containing protein	-
LP087_RS06975 (LP087_06905)	1424643..1424798	-	156	WP_264676283.1	hypothetical protein	-
LP087_RS06980 (LP087_06910)	1424935..1425420	-	486	WP_078273444.1	recombination protein NinB	-
LP087_RS06985 (LP087_06915)	1425417..1425707	-	291	WP_112742084.1	hypothetical protein	-
LP087_RS06990 (LP087_06920)	1425729..1426007	-	279	WP_078273442.1	DUF968 domain-containing protein	-
LP087_RS06995 (LP087_06925)	1426004..1426399	-	396	WP_264717794.1	VRR-NUC domain-containing protein	-
LP087_RS07000 (LP087_06930)	1426396..1427004	-	609	WP_264676191.1	hypothetical protein	-
LP087_RS07005 (LP087_06935)	1426997..1427887	-	891	WP_264676778.1	replication protein	-
LP087_RS07010 (LP087_06940)	1427884..1428567	-	684	WP_264676189.1	Rha family transcriptional regulator	-
LP087_RS07015 (LP087_06945)	1428635..1428910	-	276	WP_112742261.1	YdaS family helix-turn-helix protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1403311..1449215	45904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-79)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6761.81 Da
• Isoelectric Point: 10.7622

>T226193 WP_264676287.1 NZ_CP087800:1423372-1423554 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Nucleotide

• Length: 183 bp

>T226193 NZ_CP122317:c4408304-4408197 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15339.53 Da
• Isoelectric Point: 4.7523

>AT226193 WP_264676286.1 NZ_CP087800:1423616-1424029 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Nucleotide

• Length: 414 bp

>AT226193 NZ_CP122317:4408351-4408417 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT