Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1423372..1424029 Replicon chromosome
Accession NZ_CP087800
Organism Moraxella bovis strain SAM57953

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP087_RS06955 Protein ID WP_264676287.1
Coordinates 1423372..1423554 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP087_RS06960 Protein ID WP_264676286.1
Coordinates 1423616..1424029 (+) Length 138 a.a.

Genomic Context

LP087_RS06940LP087_RS06945LP087_RS06955LP087_RS06960LP087_RS06930LP087_RS06935LP087_RS06950LP087_RS06965LP087_RS06970LP087_RS06975LP087_RS06980LP087_RS06985LP087_RS06990LP087_RS06995LP087_RS07000LP087_RS07005LP087_RS07010LP087_RS07015
Location: 1421395..1421604 (210 bp)
Type: Others
Protein ID: WP_264676290.1
Location: 1421641..1421841 (201 bp)
Type: Others
Protein ID: WP_264676289.1
Location: 1423372..1423554 (183 bp)
Type: Toxin
Protein ID: WP_264676287.1
Location: 1423616..1424029 (414 bp)
Type: Antitoxin
Protein ID: WP_264676286.1
Location: 1419345..1420742 (1398 bp)
Type: Others
Protein ID: WP_264676292.1
Location: 1420742..1421281 (540 bp)
Type: Others
Protein ID: WP_264676291.1
Location: 1422268..1422972 (705 bp)
Type: Others
Protein ID: WP_264676288.1
Location: 1424040..1424441 (402 bp)
Type: Others
Protein ID: WP_264676285.1
Location: 1424425..1424646 (222 bp)
Type: Others
Protein ID: WP_264676284.1
Location: 1424643..1424798 (156 bp)
Type: Others
Protein ID: WP_264676283.1
Location: 1424935..1425420 (486 bp)
Type: Others
Protein ID: WP_078273444.1
Location: 1425417..1425707 (291 bp)
Type: Others
Protein ID: WP_112742084.1
Location: 1425729..1426007 (279 bp)
Type: Others
Protein ID: WP_078273442.1
Location: 1426004..1426399 (396 bp)
Type: Others
Protein ID: WP_264717794.1
Location: 1426396..1427004 (609 bp)
Type: Others
Protein ID: WP_264676191.1
Location: 1426997..1427887 (891 bp)
Type: Others
Protein ID: WP_264676778.1
Location: 1427884..1428567 (684 bp)
Type: Others
Protein ID: WP_264676189.1
Location: 1428635..1428910 (276 bp)
Type: Others
Protein ID: WP_112742261.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP087_RS06930 (LP087_06860)1419345..1420742-1398WP_264676292.1phage terminase large subunit-
LP087_RS06935 (LP087_06865)1420742..1421281-540WP_264676291.1terminase small subunit-
LP087_RS06940 (LP087_06870)1421395..1421604+210WP_264676290.1hypothetical protein-
LP087_RS06945 (LP087_06875)1421641..1421841+201WP_264676289.1helix-turn-helix domain-containing protein-
LP087_RS06950 (LP087_06880)1422268..1422972-705WP_264676288.1BRO family protein-
LP087_RS06955 (LP087_06885)1423372..1423554+183WP_264676287.1type II toxin-antitoxin system HicA family toxinToxin
LP087_RS06960 (LP087_06890)1423616..1424029+414WP_264676286.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
LP087_RS06965 (LP087_06895)1424040..1424441-402WP_264676285.1antiterminator Q family protein-
LP087_RS06970 (LP087_06900)1424425..1424646-222WP_264676284.1DUF3310 domain-containing protein-
LP087_RS06975 (LP087_06905)1424643..1424798-156WP_264676283.1hypothetical protein-
LP087_RS06980 (LP087_06910)1424935..1425420-486WP_078273444.1recombination protein NinB-
LP087_RS06985 (LP087_06915)1425417..1425707-291WP_112742084.1hypothetical protein-
LP087_RS06990 (LP087_06920)1425729..1426007-279WP_078273442.1DUF968 domain-containing protein-
LP087_RS06995 (LP087_06925)1426004..1426399-396WP_264717794.1VRR-NUC domain-containing protein-
LP087_RS07000 (LP087_06930)1426396..1427004-609WP_264676191.1hypothetical protein-
LP087_RS07005 (LP087_06935)1426997..1427887-891WP_264676778.1replication protein-
LP087_RS07010 (LP087_06940)1427884..1428567-684WP_264676189.1Rha family transcriptional regulator-
LP087_RS07015 (LP087_06945)1428635..1428910-276WP_112742261.1YdaS family helix-turn-helix protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1403311..144921545904


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226193 WP_264676287.1 NZ_CP087800:1423372-1423554 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226193 NZ_CP122317:c4408304-4408197 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226193 WP_264676286.1 NZ_CP087800:1423616-1424029 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226193 NZ_CP122317:4408351-4408417 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References