Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 673455..673998 Replicon chromosome
Accession NZ_CP087800
Organism Moraxella bovis strain SAM57953

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP087_RS03445 Protein ID WP_245952240.1
Coordinates 673771..673998 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP087_RS03440 Protein ID WP_078273964.1
Coordinates 673455..673790 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP087_RS03420 (LP087_03385) 668615..669697 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP087_RS03425 (LP087_03390) 669831..670598 - 768 WP_112742541.1 carbonic anhydrase family protein -
LP087_RS03430 (LP087_03395) 671244..672425 - 1182 WP_078274027.1 fatty acid desaturase -
LP087_RS03435 (LP087_03400) 672687..673271 + 585 Protein_661 TetR/AcrR family transcriptional regulator -
LP087_RS03440 (LP087_03405) 673455..673790 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP087_RS03445 (LP087_03410) 673771..673998 - 228 WP_245952240.1 hypothetical protein Toxin
LP087_RS03450 (LP087_03415) 674230..674937 + 708 WP_264675942.1 ParA family protein -
LP087_RS03455 (LP087_03420) 675027..676412 - 1386 WP_078273966.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8451.18 Da        Isoelectric Point: 4.5519

>T226192 WP_245952240.1 NZ_CP087800:c673998-673771 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Download         Length: 228 bp

>T226192 NZ_CP122317:c4407769-4407662 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226192 WP_078273964.1 NZ_CP087800:c673790-673455 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226192 NZ_CP122317:4407817-4407883 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References