Detailed information of TA system TA226191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 439175..439827
• Replicon: chromosome
• Accession: NZ_CP087800
• Organism: Moraxella bovis strain SAM57953

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP087_RS02225
• Protein ID: WP_078275188.1
• Coordinates: 439435..439827 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP087_RS02220
• Protein ID: WP_264675982.1
• Coordinates: 439175..439438 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP087_RS02190 (LP087_02180)	434460..435794	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP087_RS02195 (LP087_02185)	435938..436231	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP087_RS02200 (LP087_02190)	436224..436496	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP087_RS02205 (LP087_02195)	436561..437016	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP087_RS02210 (LP087_02200)	437101..437478	+	378	WP_264675984.1	hypothetical protein	-
LP087_RS02215 (LP087_02205)	437836..439095	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP087_RS02220 (LP087_02210)	439175..439438	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP087_RS02225 (LP087_02215)	439435..439827	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP087_RS02230 (LP087_02220)	439950..440480	+	531	WP_078275187.1	HI_0552 family protein	-
LP087_RS02235 (LP087_02225)	440477..441043	-	567	WP_078275186.1	hypothetical protein	-
LP087_RS02240 (LP087_02230)	441046..441282	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP087_RS02245 (LP087_02235)	441279..441737	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP087_RS02250 (LP087_02240)	441817..442839	-	1023	WP_078275183.1	hypothetical protein	-
LP087_RS02255 (LP087_02245)	442870..443748	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP087_RS02260 (LP087_02250)	443794..444735	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226191 WP_078275188.1 NZ_CP087800:439435-439827 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226191 NZ_CP122317:3803037-3803315 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226191 WP_264675982.1 NZ_CP087800:439175-439438 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226191 NZ_CP122317:3802774-3803034 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA