Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YoeB-YefM |
| Location | 1417602..1418110 | Replicon | chromosome |
| Accession | NC_010278 | ||
| Organism | Actinobacillus pleuropneumoniae serovar 3 str. JL03 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B0BQK9 |
| Locus tag | APJL_RS06380 | Protein ID | WP_005605064.1 |
| Coordinates | 1417850..1418110 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B0BQK8 |
| Locus tag | APJL_RS06375 | Protein ID | WP_005598318.1 |
| Coordinates | 1417602..1417853 (+) | Length | 84 a.a. |
Genomic Context
Location: 1415825..1417264 (1440 bp)
Type: Others
Protein ID: WP_005605060.1
Type: Others
Protein ID: WP_005605060.1
Location: 1417602..1417853 (252 bp)
Type: Antitoxin
Protein ID: WP_005598318.1
Type: Antitoxin
Protein ID: WP_005598318.1
Location: 1417850..1418110 (261 bp)
Type: Toxin
Protein ID: WP_005605064.1
Type: Toxin
Protein ID: WP_005605064.1
Location: 1421484..1421876 (393 bp)
Type: Others
Protein ID: WP_012263165.1
Type: Others
Protein ID: WP_012263165.1
Location: 1413137..1413685 (549 bp)
Type: Others
Protein ID: WP_012263163.1
Type: Others
Protein ID: WP_012263163.1
Location: 1413739..1414920 (1182 bp)
Type: Others
Protein ID: WP_005608495.1
Type: Others
Protein ID: WP_005608495.1
Location: 1418268..1418435 (168 bp)
Type: Others
Protein ID: WP_009875287.1
Type: Others
Protein ID: WP_009875287.1
Location: 1418437..1419417 (981 bp)
Type: Others
Protein ID: WP_005608502.1
Type: Others
Protein ID: WP_005608502.1
Location: 1419511..1420770 (1260 bp)
Type: Others
Protein ID: WP_005598324.1
Type: Others
Protein ID: WP_005598324.1
Location: 1420770..1421360 (591 bp)
Type: Others
Protein ID: WP_005598326.1
Type: Others
Protein ID: WP_005598326.1
Location: 1422235..1423008 (774 bp)
Type: Others
Protein ID: WP_012263166.1
Type: Others
Protein ID: WP_012263166.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APJL_RS06335 (APJL_1284) | 1413137..1413685 | - | 549 | WP_012263163.1 | type IV pilus biogenesis/stability protein PilW | - |
| APJL_RS06340 (APJL_1285) | 1413739..1414920 | - | 1182 | WP_005608495.1 | bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN | - |
| APJL_RS06365 (APJL_1286) | 1415825..1417264 | + | 1440 | WP_005605060.1 | glutamate--tRNA ligase | - |
| APJL_RS06375 (APJL_1287) | 1417602..1417853 | + | 252 | WP_005598318.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| APJL_RS06380 (APJL_1288) | 1417850..1418110 | + | 261 | WP_005605064.1 | Txe/YoeB family addiction module toxin | Toxin |
| APJL_RS06385 (APJL_1289) | 1418268..1418435 | - | 168 | WP_009875287.1 | Trm112 family protein | - |
| APJL_RS06390 (APJL_1290) | 1418437..1419417 | - | 981 | WP_005608502.1 | tetraacyldisaccharide 4'-kinase | - |
| APJL_RS06395 (APJL_1291) | 1419511..1420770 | - | 1260 | WP_005598324.1 | ATP-dependent protease ATP-binding subunit ClpX | - |
| APJL_RS06400 (APJL_1292) | 1420770..1421360 | - | 591 | WP_005598326.1 | ATP-dependent Clp endopeptidase proteolytic subunit ClpP | - |
| APJL_RS06405 (APJL_1293) | 1421484..1421876 | + | 393 | WP_012263165.1 | SufE family protein | - |
| APJL_RS06420 (APJL_1294) | 1422235..1423008 | - | 774 | WP_012263166.1 | DNA polymerase III subunit epsilon | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10423.99 Da Isoelectric Point: 8.0109
>T22619 WP_005605064.1 NC_010278:1417850-1418110 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ
Download Length: 261 bp
>T22619 NC_010278:1417850-1418110 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9362.66 Da Isoelectric Point: 4.5659
>AT22619 WP_005598318.1 NC_010278:1417602-1417853 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE
Download Length: 252 bp
>AT22619 NC_010278:1417602-1417853 [Actinobacillus pleuropneumoniae serovar 3 str. JL03]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA