Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2292889..2293547 Replicon chromosome
Accession NZ_CP087798
Organism Moraxella bovis strain SAM57954

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP098_RS11600 Protein ID WP_078274940.1
Coordinates 2293359..2293547 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP098_RS11595 Protein ID WP_112741846.1
Coordinates 2292889..2293296 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP098_RS11565 (LP098_11450) 2288120..2289949 - 1830 WP_078274936.1 hypothetical protein -
LP098_RS11570 (LP098_11455) 2289937..2290281 - 345 WP_078274937.1 hypothetical protein -
LP098_RS11575 (LP098_11460) 2290282..2291088 - 807 WP_112741850.1 hypothetical protein -
LP098_RS11580 (LP098_11465) 2291142..2291579 - 438 WP_162860346.1 hypothetical protein -
LP098_RS11585 (LP098_11470) 2291513..2291845 - 333 WP_112741848.1 hypothetical protein -
LP098_RS11590 (LP098_11475) 2291842..2292813 - 972 WP_112741847.1 phage tail tape measure protein -
LP098_RS11595 (LP098_11480) 2292889..2293296 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP098_RS11600 (LP098_11485) 2293359..2293547 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP098_RS11605 (LP098_11490) 2293690..2293905 - 216 WP_078274941.1 hypothetical protein -
LP098_RS11610 (LP098_11495) 2293907..2294506 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP098_RS11615 (LP098_11500) 2294613..2294819 - 207 WP_264676102.1 DNA-binding protein -
LP098_RS11620 (LP098_11505) 2294942..2295286 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP098_RS11625 (LP098_11510) 2295330..2296082 - 753 WP_078274945.1 hypothetical protein -
LP098_RS11630 (LP098_11515) 2296160..2296360 - 201 WP_264676324.1 hypothetical protein -
LP098_RS11635 (LP098_11520) 2296369..2296560 - 192 WP_264676101.1 DNA-binding protein -
LP098_RS11640 (LP098_11525) 2296575..2296784 - 210 WP_078274960.1 hypothetical protein -
LP098_RS11645 (LP098_11530) 2296949..2297248 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP098_RS11650 (LP098_11535) 2297443..2297730 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP098_RS11655 (LP098_11540) 2297727..2298146 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2283652..2298146 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226188 WP_078274940.1 NZ_CP087798:c2293547-2293359 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226188 NZ_CP122317:3568325-3568543 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226188 WP_112741846.1 NZ_CP087798:c2293296-2292889 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226188 NZ_CP122317:3567925-3568299 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References