Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2132449..2133098 Replicon chromosome
Accession NZ_CP087798
Organism Moraxella bovis strain SAM57954

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP098_RS10795 Protein ID WP_078274052.1
Coordinates 2132449..2132850 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP098_RS10800 Protein ID WP_112741908.1
Coordinates 2132865..2133098 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP098_RS10760 (LP098_10645) 2128105..2128338 + 234 WP_112741910.1 ASCH domain-containing protein -
LP098_RS10765 (LP098_10650) 2128384..2128533 + 150 WP_162860355.1 hypothetical protein -
LP098_RS10770 (LP098_10655) 2128530..2128949 + 420 WP_078274047.1 S4 domain-containing protein -
LP098_RS10780 (LP098_10665) 2129685..2130374 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP098_RS10785 (LP098_10670) 2130473..2131303 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP098_RS10790 (LP098_10675) 2131425..2131925 - 501 WP_112741909.1 WG repeat-containing protein -
LP098_RS10795 (LP098_10680) 2132449..2132850 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP098_RS10800 (LP098_10685) 2132865..2133098 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP098_RS10805 (LP098_10690) 2133146..2135245 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP098_RS10810 (LP098_10695) 2135466..2136059 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP098_RS10815 (LP098_10700) 2136079..2137071 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP098_RS10820 (LP098_10705) 2137253..2137702 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226187 WP_078274052.1 NZ_CP087798:c2132850-2132449 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226187 NZ_CP122317:c3240192-3239842 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226187 WP_112741908.1 NZ_CP087798:c2133098-2132865 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226187 NZ_CP122317:c3240437-3240186 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References