Detailed information of TA system TA226186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2027803..2028380
• Replicon: chromosome
• Accession: NZ_CP087798
• Organism: Moraxella bovis strain SAM57954

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP098_RS10170
• Protein ID: WP_078275234.1
• Coordinates: 2027803..2028138 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP098_RS10175
• Protein ID: WP_078275235.1
• Coordinates: 2028138..2028380 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP098_RS10145 (LP098_10035)	2023143..2023343	+	201	WP_112741955.1	hypothetical protein	-
LP098_RS10150 (LP098_10040)	2023503..2024087	+	585	WP_112741954.1	hypothetical protein	-
LP098_RS10155 (LP098_10045)	2024252..2026396	+	2145	WP_264676147.1	cation-translocating P-type ATPase	-
LP098_RS10160 (LP098_10050)	2026486..2026674	-	189	WP_143821748.1	hypothetical protein	-
LP098_RS10165 (LP098_10055)	2026746..2027741	-	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP098_RS10170 (LP098_10060)	2027803..2028138	-	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP098_RS10175 (LP098_10065)	2028138..2028380	-	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP098_RS10180 (LP098_10070)	2028587..2029666	+	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP098_RS10185 (LP098_10075)	2030048..2030770	-	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP098_RS10190 (LP098_10080)	2030959..2031585	+	627	WP_078275237.1	septation protein IspZ	-
LP098_RS10195 (LP098_10085)	2031745..2032050	+	306	WP_078275238.1	YciI family protein	-
LP098_RS10200 (LP098_10090)	2032059..2032481	+	423	WP_078275239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226186 WP_078275234.1 NZ_CP087798:c2028138-2027803 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226186 NZ_CP122317:3154831-3155088 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226186 WP_078275235.1 NZ_CP087798:c2028380-2028138 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226186 NZ_CP122317:3155100-3155645 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA