Detailed information of TA system TA226183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1623241..1623730
• Replicon: chromosome
• Accession: NZ_CP087798
• Organism: Moraxella bovis strain SAM57954

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP098_RS07970
• Protein ID: WP_112742208.1
• Coordinates: 1623241..1623498 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP098_RS07975
• Protein ID: WP_228157840.1
• Coordinates: 1623488..1623730 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP098_RS07955 (LP098_07865)	1619186..1621708	+	2523	WP_112742210.1	alpha/beta hydrolase	-
LP098_RS07960 (LP098_07870)	1621804..1622607	-	804	WP_078273307.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP098_RS07965 (LP098_07875)	1622673..1623182	-	510	WP_112742209.1	peptidylprolyl isomerase	-
LP098_RS07970 (LP098_07880)	1623241..1623498	-	258	WP_112742208.1	Txe/YoeB family addiction module toxin	Toxin
LP098_RS07975 (LP098_07885)	1623488..1623730	-	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP098_RS07980 (LP098_07890)	1623775..1623939	+	165	WP_162860378.1	hypothetical protein	-
LP098_RS07985 (LP098_07895)	1624021..1624308	-	288	WP_078273310.1	DUF1315 family protein	-
LP098_RS07990 (LP098_07900)	1624552..1625785	-	1234	Protein_1554	DUF853 family protein	-
LP098_RS07995 (LP098_07905)	1625948..1626466	-	519	WP_264676264.1	bestrophin family protein	-
LP098_RS08000 (LP098_07910)	1626456..1626668	-	213	WP_264676263.1	bestrophin family protein	-
LP098_RS08005 (LP098_07915)	1626665..1627462	-	798	WP_112742207.1	polyphenol oxidase family protein	-
LP098_RS08010 (LP098_07920)	1627581..1628630	-	1050	WP_112742206.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.99 Da
• Isoelectric Point: 7.6652

>T226183 WP_112742208.1 NZ_CP087798:c1623498-1623241 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRIDDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226183 NZ_CP122317:1782831-1783295 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226183 WP_228157840.1 NZ_CP087798:c1623730-1623488 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226183 NZ_CP122317:1782496-1782831 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA