Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1480079..1480736 Replicon chromosome
Accession NZ_CP087798
Organism Moraxella bovis strain SAM57954

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP098_RS07250 Protein ID WP_264676287.1
Coordinates 1480079..1480261 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP098_RS07255 Protein ID WP_264676286.1
Coordinates 1480323..1480736 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP098_RS07225 (LP098_07140) 1476052..1477449 - 1398 WP_264683497.1 phage terminase large subunit -
LP098_RS07230 (LP098_07145) 1477449..1477988 - 540 WP_264676291.1 terminase small subunit -
LP098_RS07235 (LP098_07150) 1478102..1478311 + 210 WP_264676290.1 hypothetical protein -
LP098_RS07240 (LP098_07155) 1478348..1478548 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP098_RS07245 (LP098_07160) 1478975..1479679 - 705 WP_264676288.1 BRO family protein -
LP098_RS07250 (LP098_07165) 1480079..1480261 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP098_RS07255 (LP098_07170) 1480323..1480736 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP098_RS07260 (LP098_07175) 1480747..1481148 - 402 WP_264676285.1 antiterminator Q family protein -
LP098_RS07265 (LP098_07180) 1481132..1481353 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP098_RS07270 (LP098_07185) 1481350..1481505 - 156 WP_264683498.1 hypothetical protein -
LP098_RS07275 (LP098_07190) 1481642..1482127 - 486 WP_078273444.1 recombination protein NinB -
LP098_RS07280 (LP098_07195) 1482191..1482868 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP098_RS07285 (LP098_07200) 1483530..1483727 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP098_RS07290 (LP098_07205) 1483774..1484052 - 279 WP_264683499.1 hypothetical protein -
LP098_RS07295 (LP098_07210) 1484049..1484456 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP098_RS07300 (LP098_07215) 1484453..1485061 - 609 WP_078273440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1460016..1511690 51674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226182 WP_264676287.1 NZ_CP087798:1480079-1480261 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226182 NZ_CP122317:c1739949-1739635 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226182 WP_264676286.1 NZ_CP087798:1480323-1480736 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226182 NZ_CP122317:c1739638-1739222 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References