Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 677664..678207 Replicon chromosome
Accession NZ_CP087798
Organism Moraxella bovis strain SAM57954

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP098_RS03460 Protein ID WP_244893652.1
Coordinates 677980..678207 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP098_RS03455 Protein ID WP_078273964.1
Coordinates 677664..677999 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP098_RS03435 (LP098_03400) 672824..673906 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP098_RS03440 (LP098_03405) 674040..674807 - 768 WP_112742541.1 carbonic anhydrase family protein -
LP098_RS03445 (LP098_03410) 675453..676634 - 1182 WP_078274027.1 fatty acid desaturase -
LP098_RS03450 (LP098_03415) 676896..677480 + 585 Protein_664 TetR/AcrR family transcriptional regulator -
LP098_RS03455 (LP098_03420) 677664..677999 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP098_RS03460 (LP098_03425) 677980..678207 - 228 WP_244893652.1 hypothetical protein Toxin
LP098_RS03465 (LP098_03430) 678439..679146 + 708 WP_078273965.1 ParA family protein -
LP098_RS03470 (LP098_03435) 679236..680621 - 1386 WP_078273966.1 APC family permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(54-104)


Sequences


Toxin        


Download         Length: 76 a.a.        Molecular weight: 8474.22 Da        Isoelectric Point: 4.7513

>T226181 WP_244893652.1 NZ_CP087798:c678207-677980 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHHDN

Download         Length: 228 bp

>T226181 NZ_CP122317:c1674038-1673742 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226181 WP_078273964.1 NZ_CP087798:c677999-677664 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226181 NZ_CP122317:c1673740-1673345 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References