Detailed information of TA system TA226180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 436041..436693
• Replicon: chromosome
• Accession: NZ_CP087798
• Organism: Moraxella bovis strain SAM57954

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP098_RS02205
• Protein ID: WP_078275188.1
• Coordinates: 436301..436693 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP098_RS02200
• Protein ID: WP_264675982.1
• Coordinates: 436041..436304 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP098_RS02170 (LP098_02155)	431326..432660	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP098_RS02175 (LP098_02160)	432804..433097	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP098_RS02180 (LP098_02165)	433090..433362	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP098_RS02185 (LP098_02170)	433427..433882	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP098_RS02190 (LP098_02175)	433967..434344	+	378	WP_264675984.1	hypothetical protein	-
LP098_RS02195 (LP098_02180)	434702..435961	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP098_RS02200 (LP098_02185)	436041..436304	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP098_RS02205 (LP098_02190)	436301..436693	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP098_RS02210 (LP098_02195)	436816..437346	+	531	WP_078275187.1	HI_0552 family protein	-
LP098_RS02215 (LP098_02200)	437343..437909	-	567	WP_078275186.1	hypothetical protein	-
LP098_RS02220 (LP098_02205)	437912..438148	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP098_RS02225 (LP098_02210)	438145..438603	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP098_RS02230 (LP098_02215)	438683..439705	-	1023	WP_078275183.1	hypothetical protein	-
LP098_RS02235 (LP098_02220)	439736..440614	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP098_RS02240 (LP098_02225)	440660..441601	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226180 WP_078275188.1 NZ_CP087798:436301-436693 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226180 NZ_CP087798:436301-436693 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226180 WP_264675982.1 NZ_CP087798:436041-436304 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226180 NZ_CP087798:436041-436304 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA