Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2421731..2422355 Replicon chromosome
Accession NZ_CP087796
Organism Moraxella bovis strain SAM57957

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP101_RS12080 Protein ID WP_264677651.1
Coordinates 2422053..2422355 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP101_RS12075 Protein ID WP_264677652.1
Coordinates 2421731..2422066 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP101_RS12050 (LP101_11960) 2416843..2417913 + 1071 WP_115368772.1 5'-nucleotidase -
LP101_RS12055 (LP101_11965) 2418122..2418439 + 318 WP_078274423.1 H-NS histone family protein -
LP101_RS12060 (LP101_11970) 2418899..2419639 + 741 WP_112742704.1 single-stranded DNA-binding protein -
LP101_RS12065 (LP101_11975) 2419814..2421046 + 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP101_RS12070 (LP101_11980) 2421234..2421698 + 465 WP_264677653.1 hypothetical protein -
LP101_RS12075 (LP101_11985) 2421731..2422066 - 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP101_RS12080 (LP101_11990) 2422053..2422355 - 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP101_RS12085 (LP101_11995) 2422493..2423848 + 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP101_RS12090 (LP101_12000) 2423958..2425076 + 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP101_RS12100 (LP101_12010) 2425095..2426450 + 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP101_RS12105 (LP101_12015) 2426707..2427261 - 555 WP_078274416.1 porin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226177 WP_264677651.1 NZ_CP087796:c2422355-2422053 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226177 NZ_CP122317:1296531-1297604 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226177 WP_264677652.1 NZ_CP087796:c2422066-2421731 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226177 NZ_CP122317:1297597-1297968 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References