Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 641313..641856 Replicon chromosome
Accession NZ_CP087796
Organism Moraxella bovis strain SAM57957

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP101_RS03075 Protein ID WP_245952240.1
Coordinates 641629..641856 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP101_RS03070 Protein ID WP_078273964.1
Coordinates 641313..641648 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP101_RS03045 (LP101_03025) 636472..637554 - 1083 WP_264677155.1 tRNA pseudouridine(13) synthase TruD -
LP101_RS03050 (LP101_03030) 637658..638092 - 435 WP_264677154.1 carbonic anhydrase family protein -
LP101_RS03055 (LP101_03035) 638104..638454 - 351 WP_264677153.1 hypothetical protein -
LP101_RS03060 (LP101_03040) 639101..640282 - 1182 WP_264678410.1 fatty acid desaturase -
LP101_RS03065 (LP101_03045) 640545..641129 + 585 Protein_584 TetR/AcrR family transcriptional regulator -
LP101_RS03070 (LP101_03050) 641313..641648 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP101_RS03075 (LP101_03055) 641629..641856 - 228 WP_245952240.1 hypothetical protein Toxin
LP101_RS03080 (LP101_03060) 642088..642796 + 709 Protein_587 ParA family protein -
LP101_RS03085 (LP101_03065) 642886..644271 - 1386 WP_078273966.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8451.18 Da        Isoelectric Point: 4.5519

>T226172 WP_245952240.1 NZ_CP087796:c641856-641629 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Download         Length: 228 bp

>T226172 NZ_CP122317:c177144-176857 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226172 WP_078273964.1 NZ_CP087796:c641648-641313 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226172 NZ_CP122317:c177383-177144 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References