Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 362077..362729 Replicon chromosome
Accession NZ_CP087796
Organism Moraxella bovis strain SAM57957

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP101_RS01660 Protein ID WP_264677325.1
Coordinates 362337..362729 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP101_RS01655 Protein ID WP_264675982.1
Coordinates 362077..362340 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP101_RS01615 (LP101_01585) 357156..357359 + 204 WP_115368689.1 hypothetical protein -
LP101_RS01620 (LP101_01590) 357479..358813 + 1335 WP_264677331.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP101_RS01625 (LP101_01595) 358957..359250 + 294 WP_264677330.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP101_RS01630 (LP101_01600) 359243..359515 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP101_RS01635 (LP101_01605) 359580..360035 - 456 WP_264677329.1 type IV secretion protein Rhs -
LP101_RS01640 (LP101_01610) 360095..360364 + 270 WP_264677328.1 hypothetical protein -
LP101_RS01645 (LP101_01615) 360361..360741 + 381 WP_264677327.1 type II toxin-antitoxin system VapC family toxin -
LP101_RS01650 (LP101_01620) 360738..361997 + 1260 WP_264677326.1 replication-associated recombination protein A -
LP101_RS01655 (LP101_01625) 362077..362340 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP101_RS01660 (LP101_01630) 362337..362729 + 393 WP_264677325.1 type II toxin-antitoxin system VapC family toxin Toxin
LP101_RS01665 (LP101_01635) 362852..363382 + 531 WP_264678418.1 glucose-6-phosphate 1-dehydrogenase family protein -
LP101_RS01670 (LP101_01640) 363379..363945 - 567 WP_078275186.1 hypothetical protein -
LP101_RS01675 (LP101_01645) 363948..364184 - 237 WP_078275185.1 sulfurtransferase TusA -
LP101_RS01680 (LP101_01650) 364181..364639 - 459 WP_264677324.1 acyl-CoA thioesterase -
LP101_RS01685 (LP101_01655) 364718..365740 - 1023 WP_264677323.1 hypothetical protein -
LP101_RS01690 (LP101_01660) 365771..366649 - 879 WP_264677322.1 uroporphyrinogen-III synthase -
LP101_RS01695 (LP101_01665) 366695..367636 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14629.69 Da        Isoelectric Point: 4.7370

>T226171 WP_264677325.1 NZ_CP087796:362337-362729 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226171 NZ_CP122317:c123686-122364 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226171 WP_264675982.1 NZ_CP087796:362077-362340 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226171 NZ_CP122317:c123952-123686 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References