22617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2356581..2357559 Replicon chromosome
Accession NC_010184
Organism Bacillus weihenstephanensis KBAB4

Toxin (Protein)


Gene name spoIISA Uniprot ID R8N1U0
Locus tag BCERKBAB4_RS11700 Protein ID WP_002032139.1
Coordinates 2356581..2357321 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BCERKBAB4_RS11705 Protein ID WP_000588712.1
Coordinates 2357434..2357559 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCERKBAB4_RS11670 2351727..2352443 + 717 WP_012260945.1 ABC transporter ATP-binding protein -
BCERKBAB4_RS11675 2352550..2353260 + 711 WP_002141778.1 class I SAM-dependent methyltransferase -
BCERKBAB4_RS11680 2353379..2353792 + 414 WP_002141779.1 VOC family protein -
BCERKBAB4_RS11685 2353969..2354601 - 633 WP_002017047.1 glutamine amidotransferase -
BCERKBAB4_RS11690 2354875..2355351 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
BCERKBAB4_RS11695 2355505..2356242 + 738 WP_002141781.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BCERKBAB4_RS11700 2356581..2357321 + 741 WP_002032139.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BCERKBAB4_RS11705 2357434..2357559 + 126 WP_000588712.1 hypothetical protein Antitoxin
BCERKBAB4_RS31575 2357635..2357811 + 177 WP_002141782.1 hypothetical protein -
BCERKBAB4_RS11715 2357855..2358130 - 276 WP_002141783.1 hypothetical protein -
BCERKBAB4_RS11720 2358157..2358687 - 531 WP_040963068.1 hypothetical protein -
BCERKBAB4_RS32015 2359009..2359185 + 177 WP_002141786.1 hypothetical protein -
BCERKBAB4_RS11730 2359261..2359642 - 382 Protein_2291 YxeA family protein -
BCERKBAB4_RS11735 2359897..2361366 + 1470 WP_002141788.1 aminoacyl-histidine dipeptidase -
BCERKBAB4_RS32020 2361726..2361875 + 150 WP_002141789.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28482.11 Da        Isoelectric Point: 8.3034

>T22617 WP_002032139.1 NC_010184:2356581-2357321 [Bacillus mycoides KBAB4]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T22617 NC_010184:2356581-2357321 [Bacillus mycoides KBAB4]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT22617 WP_000588712.1 NC_010184:2357434-2357559 [Bacillus mycoides KBAB4]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT22617 NC_010184:2357434-2357559 [Bacillus mycoides KBAB4]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8N1U0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References