Detailed information of TA system TA226168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2287220..2287778
• Replicon: chromosome
• Accession: NZ_CP087793
• Organism: Moraxella bovis strain SAM57959

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP112_RS11710
• Protein ID: WP_228157760.1
• Coordinates: 2287220..2287492 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP112_RS11715
• Protein ID: WP_029103533.1
• Coordinates: 2287485..2287778 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP112_RS11670 (LP112_11565)	2282434..2282670	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP112_RS11675 (LP112_11570)	2282673..2283239	+	567	WP_078275186.1	hypothetical protein	-
LP112_RS11680 (LP112_11575)	2283236..2283766	-	531	WP_078275187.1	HI_0552 family protein	-
LP112_RS11685 (LP112_11580)	2283889..2284281	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP112_RS11690 (LP112_11585)	2284278..2284541	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP112_RS11695 (LP112_11590)	2284621..2285880	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP112_RS11700 (LP112_11595)	2286238..2286615	-	378	WP_264675984.1	hypothetical protein	-
LP112_RS11705 (LP112_11600)	2286700..2287155	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP112_RS11710 (LP112_11605)	2287220..2287492	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP112_RS11715 (LP112_11610)	2287485..2287778	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP112_RS11720 (LP112_11615)	2287922..2289256	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP112_RS11725 (LP112_11620)	2289465..2290181	-	717	WP_078275193.1	hypothetical protein	-
LP112_RS11730 (LP112_11625)	2290202..2290813	-	612	WP_112741794.1	methyltransferase	-
LP112_RS11735 (LP112_11630)	2290933..2292267	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226168 WP_228157760.1 NZ_CP087793:c2287492-2287220 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226168 NZ_CP122316:4447468-4447875 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226168 WP_029103533.1 NZ_CP087793:c2287778-2287485 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226168 NZ_CP122316:4447221-4447487 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6