Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2283889..2284541 Replicon chromosome
Accession NZ_CP087793
Organism Moraxella bovis strain SAM57959

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP112_RS11685 Protein ID WP_078275188.1
Coordinates 2283889..2284281 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP112_RS11690 Protein ID WP_264675982.1
Coordinates 2284278..2284541 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP112_RS11650 (LP112_11545) 2278981..2279922 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP112_RS11655 (LP112_11550) 2279968..2280846 + 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP112_RS11660 (LP112_11555) 2280877..2281899 + 1023 WP_078275183.1 hypothetical protein -
LP112_RS11665 (LP112_11560) 2281979..2282437 + 459 WP_078275184.1 acyl-CoA thioesterase -
LP112_RS11670 (LP112_11565) 2282434..2282670 + 237 WP_078275185.1 sulfurtransferase TusA -
LP112_RS11675 (LP112_11570) 2282673..2283239 + 567 WP_078275186.1 hypothetical protein -
LP112_RS11680 (LP112_11575) 2283236..2283766 - 531 WP_078275187.1 HI_0552 family protein -
LP112_RS11685 (LP112_11580) 2283889..2284281 - 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP112_RS11690 (LP112_11585) 2284278..2284541 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP112_RS11695 (LP112_11590) 2284621..2285880 - 1260 WP_264675983.1 replication-associated recombination protein A -
LP112_RS11700 (LP112_11595) 2286238..2286615 - 378 WP_264675984.1 hypothetical protein -
LP112_RS11705 (LP112_11600) 2286700..2287155 + 456 WP_264675985.1 type IV secretion protein Rhs -
LP112_RS11710 (LP112_11605) 2287220..2287492 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP112_RS11715 (LP112_11610) 2287485..2287778 - 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP112_RS11720 (LP112_11615) 2287922..2289256 - 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226167 WP_078275188.1 NZ_CP087793:c2284281-2283889 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226167 NZ_CP122316:4344866-4345162 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226167 WP_264675982.1 NZ_CP087793:c2284541-2284278 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226167 NZ_CP122316:4345164-4345559 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References