Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1304661..1305318 Replicon chromosome
Accession NZ_CP087793
Organism Moraxella bovis strain SAM57959

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP112_RS06970 Protein ID WP_264676287.1
Coordinates 1305136..1305318 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP112_RS06965 Protein ID WP_264676286.1
Coordinates 1304661..1305074 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP112_RS06910 (LP112_06865) 1299841..1300557 + 717 WP_264676717.1 phage regulatory protein/antirepressor Ant -
LP112_RS06915 (LP112_06870) 1300554..1300871 + 318 WP_078273437.1 hypothetical protein -
LP112_RS06920 (LP112_06875) 1300868..1301677 + 810 WP_264683005.1 replication protein -
LP112_RS06925 (LP112_06880) 1301674..1302282 + 609 WP_078273440.1 hypothetical protein -
LP112_RS06930 (LP112_06885) 1302279..1302686 + 408 WP_264698018.1 VRR-NUC domain-containing protein -
LP112_RS06935 (LP112_06890) 1302683..1302961 + 279 WP_264676282.1 hypothetical protein -
LP112_RS06940 (LP112_06895) 1302983..1303273 + 291 WP_112742084.1 hypothetical protein -
LP112_RS06945 (LP112_06900) 1303270..1303755 + 486 WP_078273444.1 recombination protein NinB -
LP112_RS06950 (LP112_06905) 1303892..1304047 + 156 WP_264676283.1 hypothetical protein -
LP112_RS06955 (LP112_06910) 1304044..1304265 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP112_RS06960 (LP112_06915) 1304249..1304650 + 402 WP_264698038.1 antiterminator Q family protein -
LP112_RS06965 (LP112_06920) 1304661..1305074 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP112_RS06970 (LP112_06925) 1305136..1305318 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP112_RS06975 (LP112_06930) 1305718..1306422 + 705 WP_264676288.1 BRO family protein -
LP112_RS06980 (LP112_06935) 1306849..1307049 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP112_RS06985 (LP112_06940) 1307086..1307295 - 210 WP_264676290.1 hypothetical protein -
LP112_RS06990 (LP112_06945) 1307409..1307948 + 540 WP_264676291.1 terminase small subunit -
LP112_RS06995 (LP112_06950) 1307948..1309345 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1285936..1325379 39443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226165 WP_264676287.1 NZ_CP087793:c1305318-1305136 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226165 NZ_CP122316:c4236073-4235609 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226165 WP_264676286.1 NZ_CP087793:c1305074-1304661 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226165 NZ_CP122316:c4236408-4236073 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References