Detailed information of TA system TA226163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 959572..960124
• Replicon: chromosome
• Accession: NZ_CP087793
• Organism: Moraxella bovis strain SAM57959

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP112_RS05090
• Protein ID: WP_029102268.1
• Coordinates: 959846..960124 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP112_RS05085
• Protein ID: WP_078273473.1
• Coordinates: 959572..959859 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP112_RS05065 (LP112_05050)	955007..956056	+	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP112_RS05070 (LP112_05055)	956135..957634	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP112_RS05075	957663..957788	+	126	WP_264676709.1	hypothetical protein	-
LP112_RS05080 (LP112_05060)	957832..959562	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP112_RS05085 (LP112_05065)	959572..959859	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP112_RS05090 (LP112_05070)	959846..960124	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP112_RS05095 (LP112_05075)	960219..960875	-	657	WP_078273472.1	YqiJ family protein	-
LP112_RS05100 (LP112_05080)	961075..961740	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP112_RS05105 (LP112_05085)	961953..962243	-	291	WP_264676229.1	hypothetical protein	-
LP112_RS05110 (LP112_05090)	962236..962751	-	516	WP_115369660.1	hypothetical protein	-
LP112_RS05115 (LP112_05095)	962899..963249	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP112_RS05120 (LP112_05100)	963361..964137	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226163 WP_029102268.1 NZ_CP087793:c960124-959846 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226163 NZ_CP122316:c2909860-2909519 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226163 WP_078273473.1 NZ_CP087793:c959859-959572 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226163 NZ_CP122316:2909855-2909931 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3