Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 634594..635243 Replicon chromosome
Accession NZ_CP087793
Organism Moraxella bovis strain SAM57959

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP112_RS03260 Protein ID WP_078274052.1
Coordinates 634842..635243 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP112_RS03255 Protein ID WP_112741908.1
Coordinates 634594..634827 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP112_RS03235 (LP112_03230) 629990..630439 - 450 WP_264676133.1 cytochrome c -
LP112_RS03240 (LP112_03235) 630621..631613 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP112_RS03245 (LP112_03240) 631633..632226 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP112_RS03250 (LP112_03245) 632447..634546 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP112_RS03255 (LP112_03250) 634594..634827 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP112_RS03260 (LP112_03255) 634842..635243 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP112_RS03265 (LP112_03260) 635767..636267 + 501 WP_112741909.1 WG repeat-containing protein -
LP112_RS03270 (LP112_03265) 636389..637219 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP112_RS03275 (LP112_03270) 637318..638007 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP112_RS03285 (LP112_03280) 638743..639162 - 420 WP_078274047.1 S4 domain-containing protein -
LP112_RS03290 (LP112_03285) 639159..639335 - 177 WP_228157829.1 ASCH domain-containing protein -
LP112_RS03295 (LP112_03290) 639354..639587 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226160 WP_078274052.1 NZ_CP087793:634842-635243 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226160 NZ_CP122316:c2450579-2450361 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226160 WP_112741908.1 NZ_CP087793:634594-634827 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226160 NZ_CP122316:c2450979-2450605 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References