Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 474146..474804 Replicon chromosome
Accession NZ_CP087793
Organism Moraxella bovis strain SAM57959

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP112_RS02460 Protein ID WP_078274940.1
Coordinates 474146..474334 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP112_RS02465 Protein ID WP_112741846.1
Coordinates 474397..474804 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP112_RS02405 (LP112_02400) 469547..469966 - 420 WP_112741841.1 S24 family peptidase -
LP112_RS02410 (LP112_02405) 469963..470250 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP112_RS02415 (LP112_02410) 470445..470744 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP112_RS02420 (LP112_02415) 470909..471118 + 210 WP_078274960.1 hypothetical protein -
LP112_RS02425 (LP112_02420) 471133..471324 + 192 WP_264676101.1 DNA-binding protein -
LP112_RS02430 (LP112_02425) 471333..471533 + 201 WP_264676324.1 hypothetical protein -
LP112_RS02435 (LP112_02430) 471611..472363 + 753 WP_078274945.1 hypothetical protein -
LP112_RS02440 (LP112_02435) 472407..472751 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP112_RS02445 (LP112_02440) 472874..473080 + 207 WP_264676102.1 DNA-binding protein -
LP112_RS02450 (LP112_02445) 473187..473786 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP112_RS02455 (LP112_02450) 473788..474003 + 216 WP_078274941.1 hypothetical protein -
LP112_RS02460 (LP112_02455) 474146..474334 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP112_RS02465 (LP112_02460) 474397..474804 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP112_RS02470 (LP112_02465) 474880..475851 + 972 WP_112741847.1 phage tail tape measure protein -
LP112_RS02475 (LP112_02470) 475848..476180 + 333 WP_112741848.1 hypothetical protein -
LP112_RS02480 (LP112_02475) 476114..476551 + 438 WP_162860346.1 hypothetical protein -
LP112_RS02485 (LP112_02480) 476605..477411 + 807 WP_112741850.1 hypothetical protein -
LP112_RS02490 (LP112_02485) 477412..477756 + 345 WP_078274937.1 hypothetical protein -
LP112_RS02495 (LP112_02490) 477744..479573 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 469547..484041 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226159 WP_078274940.1 NZ_CP087793:474146-474334 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226159 NZ_CP122316:c2232212-2231871 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226159 WP_112741846.1 NZ_CP087793:474397-474804 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226159 NZ_CP122316:c2232550-2232233 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References