Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2250024..2250676 Replicon chromosome
Accession NZ_CP087791
Organism Moraxella bovis strain SAM57964

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP090_RS11440 Protein ID WP_264677325.1
Coordinates 2250024..2250416 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP090_RS11445 Protein ID WP_264675982.1
Coordinates 2250413..2250676 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP090_RS11405 (LP090_11320) 2245117..2246058 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP090_RS11410 (LP090_11325) 2246104..2246982 + 879 WP_264677322.1 uroporphyrinogen-III synthase -
LP090_RS11415 (LP090_11330) 2247013..2248035 + 1023 WP_264677323.1 hypothetical protein -
LP090_RS11420 (LP090_11335) 2248114..2248572 + 459 WP_264677324.1 acyl-CoA thioesterase -
LP090_RS11425 (LP090_11340) 2248569..2248805 + 237 WP_078275185.1 sulfurtransferase TusA -
LP090_RS11430 (LP090_11345) 2248808..2249374 + 567 WP_078275186.1 hypothetical protein -
LP090_RS11435 (LP090_11350) 2249371..2249901 - 531 WP_264678418.1 glucose-6-phosphate 1-dehydrogenase family protein -
LP090_RS11440 (LP090_11355) 2250024..2250416 - 393 WP_264677325.1 type II toxin-antitoxin system VapC family toxin Toxin
LP090_RS11445 (LP090_11360) 2250413..2250676 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP090_RS11450 (LP090_11365) 2250756..2252015 - 1260 WP_264677326.1 replication-associated recombination protein A -
LP090_RS11455 (LP090_11370) 2252012..2252392 - 381 WP_264677327.1 type II toxin-antitoxin system VapC family toxin -
LP090_RS11460 (LP090_11375) 2252389..2252658 - 270 WP_264677328.1 hypothetical protein -
LP090_RS11465 (LP090_11380) 2252718..2253173 + 456 WP_264677329.1 type IV secretion protein Rhs -
LP090_RS11470 (LP090_11385) 2253238..2253510 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP090_RS11475 (LP090_11390) 2253503..2253796 - 294 WP_264677330.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP090_RS11480 (LP090_11395) 2253940..2255274 - 1335 WP_264677331.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP090_RS11485 (LP090_11400) 2255394..2255597 - 204 WP_115368689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14629.69 Da        Isoelectric Point: 4.7370

>T226157 WP_264677325.1 NZ_CP087791:c2250416-2250024 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226157 NZ_CP122316:c2215558-2215280 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226157 WP_264675982.1 NZ_CP087791:c2250676-2250413 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226157 NZ_CP122316:c2215821-2215561 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References