Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1967886..1968462 Replicon chromosome
Accession NZ_CP087791
Organism Moraxella bovis strain SAM57964

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP090_RS10025 Protein ID WP_264676341.1
Coordinates 1967886..1968146 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP090_RS10030 Protein ID WP_078273964.1
Coordinates 1968127..1968462 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP090_RS10010 (LP090_09935) 1962917..1964992 + 2076 WP_264677152.1 NAD-dependent DNA ligase LigA -
LP090_RS10015 (LP090_09940) 1965504..1966889 + 1386 WP_078273966.1 APC family permease -
LP090_RS10020 (LP090_09945) 1966979..1967687 - 709 Protein_1963 ParA family protein -
LP090_RS10025 (LP090_09950) 1967886..1968146 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP090_RS10030 (LP090_09955) 1968127..1968462 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP090_RS10035 (LP090_09960) 1968646..1969230 - 585 Protein_1966 TetR/AcrR family transcriptional regulator -
LP090_RS10040 (LP090_09965) 1969493..1970674 + 1182 WP_264678410.1 fatty acid desaturase -
LP090_RS10045 (LP090_09970) 1971321..1971671 + 351 WP_264677153.1 hypothetical protein -
LP090_RS10050 (LP090_09975) 1971683..1972117 + 435 WP_264677154.1 carbonic anhydrase family protein -
LP090_RS10055 (LP090_09980) 1972221..1973303 + 1083 WP_264677155.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226156 WP_264676341.1 NZ_CP087791:1967886-1968146 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226156 NZ_CP122316:1610826-1610933 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226156 WP_078273964.1 NZ_CP087791:1968127-1968462 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226156 NZ_CP122316:c1610776-1610713 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References