Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1314184..1314841 Replicon chromosome
Accession NZ_CP087791
Organism Moraxella bovis strain SAM57964

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP090_RS06805 Protein ID WP_264676287.1
Coordinates 1314184..1314366 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP090_RS06810 Protein ID WP_264676286.1
Coordinates 1314428..1314841 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP090_RS06785 (LP090_06730) 1309315..1310733 - 1419 WP_264676198.1 DUF4055 domain-containing protein -
LP090_RS06790 (LP090_06735) 1310733..1312205 - 1473 WP_264676776.1 terminase -
LP090_RS06795 (LP090_06740) 1312205..1312630 - 426 WP_264676196.1 hypothetical protein -
LP090_RS06800 (LP090_06745) 1313080..1313784 - 705 WP_264676288.1 BRO family protein -
LP090_RS06805 (LP090_06750) 1314184..1314366 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP090_RS06810 (LP090_06755) 1314428..1314841 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP090_RS06815 (LP090_06760) 1314852..1315253 - 402 WP_264676285.1 antiterminator Q family protein -
LP090_RS06820 (LP090_06765) 1315237..1315458 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP090_RS06825 (LP090_06770) 1315455..1315610 - 156 WP_264676283.1 hypothetical protein -
LP090_RS06830 (LP090_06775) 1315747..1316232 - 486 WP_264676777.1 recombination protein NinB -
LP090_RS06835 (LP090_06780) 1316229..1316519 - 291 WP_112742084.1 hypothetical protein -
LP090_RS06840 (LP090_06785) 1316541..1316819 - 279 WP_115369598.1 DUF968 domain-containing protein -
LP090_RS06845 (LP090_06790) 1316816..1317319 - 504 WP_079326170.1 hypothetical protein -
LP090_RS06850 (LP090_06795) 1317316..1317708 - 393 WP_115369748.1 VRR-NUC domain-containing protein -
LP090_RS06855 (LP090_06800) 1317705..1318313 - 609 WP_264676191.1 hypothetical protein -
LP090_RS06860 (LP090_06805) 1318306..1319196 - 891 WP_264676778.1 replication protein -
LP090_RS06865 (LP090_06810) 1319193..1319747 - 555 WP_264676779.1 Rha family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1265183..1339828 74645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226154 WP_264676287.1 NZ_CP087791:1314184-1314366 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226154 NZ_CP122316:1609756-1609863 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226154 WP_264676286.1 NZ_CP087791:1314428-1314841 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226154 NZ_CP122316:c1609709-1609643 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References