Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 643711..644360 Replicon chromosome
Accession NZ_CP087791
Organism Moraxella bovis strain SAM57964

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP090_RS03395 Protein ID WP_264677937.1
Coordinates 643959..644360 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP090_RS03390 Protein ID WP_112741908.1
Coordinates 643711..643944 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP090_RS03370 (LP090_03340) 639107..639556 - 450 WP_249097919.1 cytochrome c -
LP090_RS03375 (LP090_03345) 639738..640730 - 993 WP_264677935.1 oxygen-dependent coproporphyrinogen oxidase -
LP090_RS03380 (LP090_03350) 640750..641343 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP090_RS03385 (LP090_03355) 641564..643663 + 2100 WP_264677936.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP090_RS03390 (LP090_03360) 643711..643944 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP090_RS03395 (LP090_03365) 643959..644360 + 402 WP_264677937.1 type II toxin-antitoxin system VapC family toxin Toxin
LP090_RS03400 (LP090_03370) 644884..645384 + 501 WP_112741909.1 WG repeat-containing protein -
LP090_RS03405 (LP090_03375) 645506..646336 + 831 WP_264677938.1 inositol monophosphatase family protein -
LP090_RS03410 (LP090_03380) 646436..647125 - 690 WP_264677939.1 SIMPL domain-containing protein -
LP090_RS03420 (LP090_03390) 647863..648282 - 420 WP_264677940.1 S4 domain-containing protein -
LP090_RS03425 (LP090_03395) 648534..648707 - 174 WP_264677941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.29 Da        Isoelectric Point: 6.8426

>T226150 WP_264677937.1 NZ_CP087791:643959-644360 [Moraxella bovis]
MFSFMLDTNICIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226150 NZ_CP122316:958093-958196 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226150 WP_112741908.1 NZ_CP087791:643711-643944 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226150 NZ_CP122316:c958234-957963 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References