Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 200309..200933 Replicon chromosome
Accession NZ_CP087791
Organism Moraxella bovis strain SAM57964

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP090_RS01080 Protein ID WP_264677651.1
Coordinates 200309..200611 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP090_RS01085 Protein ID WP_264677652.1
Coordinates 200598..200933 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP090_RS01055 (LP090_01040) 195403..195957 + 555 WP_078274416.1 porin family protein -
LP090_RS01060 (LP090_01045) 196214..197569 - 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP090_RS01070 (LP090_01055) 197588..198706 - 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP090_RS01075 (LP090_01060) 198816..200171 - 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP090_RS01080 (LP090_01065) 200309..200611 + 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP090_RS01085 (LP090_01070) 200598..200933 + 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP090_RS01090 (LP090_01075) 200966..201430 - 465 WP_264677653.1 hypothetical protein -
LP090_RS01095 (LP090_01080) 201618..202850 - 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP090_RS01100 (LP090_01085) 203025..203765 - 741 WP_112742704.1 single-stranded DNA-binding protein -
LP090_RS01105 (LP090_01090) 204225..204542 - 318 WP_078274423.1 H-NS histone family protein -
LP090_RS01110 (LP090_01095) 204751..205821 - 1071 WP_115368772.1 5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226149 WP_264677651.1 NZ_CP087791:200309-200611 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226149 NZ_CP122316:c804507-804133 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226149 WP_264677652.1 NZ_CP087791:200598-200933 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226149 NZ_CP122316:c804964-804596 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References