Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2250793..2251451 | Replicon | chromosome |
| Accession | NZ_CP087784 | ||
| Organism | Moraxella bovis strain SAM57973 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP100_RS11425 | Protein ID | WP_078274940.1 |
| Coordinates | 2251263..2251451 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP100_RS11420 | Protein ID | WP_112741846.1 |
| Coordinates | 2250793..2251200 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP100_RS11390 (LP100_11290) | 2246024..2247853 | - | 1830 | WP_078274936.1 | hypothetical protein | - |
| LP100_RS11395 (LP100_11295) | 2247841..2248185 | - | 345 | WP_078274937.1 | hypothetical protein | - |
| LP100_RS11400 (LP100_11300) | 2248186..2248992 | - | 807 | WP_112741850.1 | hypothetical protein | - |
| LP100_RS11405 (LP100_11305) | 2249046..2249483 | - | 438 | WP_162860346.1 | hypothetical protein | - |
| LP100_RS11410 (LP100_11310) | 2249417..2249749 | - | 333 | WP_112741848.1 | hypothetical protein | - |
| LP100_RS11415 (LP100_11315) | 2249746..2250717 | - | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP100_RS11420 (LP100_11320) | 2250793..2251200 | - | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP100_RS11425 (LP100_11325) | 2251263..2251451 | - | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP100_RS11430 (LP100_11330) | 2251594..2251809 | - | 216 | WP_078274941.1 | hypothetical protein | - |
| LP100_RS11435 (LP100_11335) | 2251811..2252410 | - | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP100_RS11440 (LP100_11340) | 2252517..2252723 | - | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP100_RS11445 (LP100_11345) | 2252846..2253190 | + | 345 | WP_078274944.1 | helix-turn-helix transcriptional regulator | - |
| LP100_RS11450 (LP100_11350) | 2253234..2253986 | - | 753 | WP_078274945.1 | hypothetical protein | - |
| LP100_RS11455 (LP100_11355) | 2254064..2254264 | - | 201 | WP_264676324.1 | hypothetical protein | - |
| LP100_RS11460 (LP100_11360) | 2254273..2254464 | - | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP100_RS11465 (LP100_11365) | 2254479..2254688 | - | 210 | WP_078274960.1 | hypothetical protein | - |
| LP100_RS11470 (LP100_11370) | 2254853..2255152 | + | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP100_RS11475 (LP100_11375) | 2255347..2255634 | + | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP100_RS11480 (LP100_11380) | 2255631..2256050 | + | 420 | WP_112741841.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2241556..2262696 | 21140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226148 WP_078274940.1 NZ_CP087784:c2251451-2251263 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226148 NZ_CP122316:792611-792865 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226148 WP_112741846.1 NZ_CP087784:c2251200-2250793 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226148 NZ_CP122316:792363-792614 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|