Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2090424..2091073 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP100_RS10625 Protein ID WP_078274052.1
Coordinates 2090424..2090825 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP100_RS10630 Protein ID WP_112741908.1
Coordinates 2090840..2091073 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP100_RS10590 (LP100_10490) 2086080..2086313 + 234 WP_112741910.1 ASCH domain-containing protein -
LP100_RS10595 (LP100_10495) 2086359..2086508 + 150 WP_162860355.1 hypothetical protein -
LP100_RS10600 (LP100_10500) 2086505..2086924 + 420 WP_078274047.1 S4 domain-containing protein -
LP100_RS10610 (LP100_10510) 2087660..2088349 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP100_RS10615 (LP100_10515) 2088448..2089278 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP100_RS10620 (LP100_10520) 2089400..2089900 - 501 WP_112741909.1 WG repeat-containing protein -
LP100_RS10625 (LP100_10525) 2090424..2090825 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP100_RS10630 (LP100_10530) 2090840..2091073 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP100_RS10635 (LP100_10535) 2091121..2093220 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP100_RS10640 (LP100_10540) 2093441..2094034 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP100_RS10645 (LP100_10545) 2094054..2095046 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP100_RS10650 (LP100_10550) 2095228..2095677 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226147 WP_078274052.1 NZ_CP087784:c2090825-2090424 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226147 NZ_CP122316:792363-792614 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226147 WP_112741908.1 NZ_CP087784:c2091073-2090840 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226147 NZ_CP122316:792611-792865 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References