Detailed information of TA system TA226144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1777944..1778496
• Replicon: chromosome
• Accession: NZ_CP087784
• Organism: Moraxella bovis strain SAM57973

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP100_RS08895
• Protein ID: WP_029102268.1
• Coordinates: 1777944..1778222 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP100_RS08900
• Protein ID: WP_078273473.1
• Coordinates: 1778209..1778496 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP100_RS08865 (LP100_08775)	1773931..1774707	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP100_RS08870 (LP100_08780)	1774819..1775169	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP100_RS08875 (LP100_08785)	1775317..1775832	+	516	WP_115369660.1	hypothetical protein	-
LP100_RS08880 (LP100_08790)	1775825..1776115	+	291	WP_264676229.1	hypothetical protein	-
LP100_RS08885 (LP100_08795)	1776328..1776993	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP100_RS08890 (LP100_08800)	1777193..1777849	+	657	WP_078273472.1	YqiJ family protein	-
LP100_RS08895 (LP100_08805)	1777944..1778222	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP100_RS08900 (LP100_08810)	1778209..1778496	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP100_RS08905 (LP100_08815)	1778506..1780236	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP100_RS08910 (LP100_08820)	1780434..1781933	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP100_RS08915 (LP100_08825)	1782012..1783061	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226144 WP_029102268.1 NZ_CP087784:1777944-1778222 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226144 NZ_CP122315:c4553976-4553680 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226144 WP_078273473.1 NZ_CP087784:1778209-1778496 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226144 NZ_CP122315:c4553678-4553283 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3