Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1431655..1432312 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP100_RS07020 Protein ID WP_264676287.1
Coordinates 1431655..1431837 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP100_RS07025 Protein ID WP_264676286.1
Coordinates 1431899..1432312 (+) Length 138 a.a.

Genomic Context

LP100_RS07005LP100_RS07010LP100_RS07020LP100_RS07025LP100_RS07055LP100_RS06995LP100_RS07000LP100_RS07015LP100_RS07030LP100_RS07035LP100_RS07040LP100_RS07045LP100_RS07050LP100_RS07060LP100_RS07065LP100_RS07070
Location: 1429678..1429887 (210 bp)
Type: Others
Protein ID: WP_264676290.1
Location: 1429924..1430124 (201 bp)
Type: Others
Protein ID: WP_264676289.1
Location: 1431655..1431837 (183 bp)
Type: Toxin
Protein ID: WP_264676287.1
Location: 1431899..1432312 (414 bp)
Type: Antitoxin
Protein ID: WP_264676286.1
Location: 1435106..1435303 (198 bp)
Type: Others
Protein ID: WP_264682993.1
Location: 1427628..1429025 (1398 bp)
Type: Others
Protein ID: WP_264676292.1
Location: 1429025..1429564 (540 bp)
Type: Others
Protein ID: WP_264676291.1
Location: 1430551..1431255 (705 bp)
Type: Others
Protein ID: WP_264676288.1
Location: 1432323..1432724 (402 bp)
Type: Others
Protein ID: WP_264676285.1
Location: 1432708..1432929 (222 bp)
Type: Others
Protein ID: WP_264676284.1
Location: 1432926..1433081 (156 bp)
Type: Others
Protein ID: WP_264676283.1
Location: 1433218..1433703 (486 bp)
Type: Others
Protein ID: WP_078273444.1
Location: 1433767..1434444 (678 bp)
Type: Others
Protein ID: WP_264682991.1
Location: 1435350..1435628 (279 bp)
Type: Others
Protein ID: WP_264682994.1
Location: 1435625..1436032 (408 bp)
Type: Others
Protein ID: WP_112742083.1
Location: 1436029..1436637 (609 bp)
Type: Others
Protein ID: WP_264676191.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP100_RS06995 (LP100_06920)1427628..1429025-1398WP_264676292.1phage terminase large subunit-
LP100_RS07000 (LP100_06925)1429025..1429564-540WP_264676291.1terminase small subunit-
LP100_RS07005 (LP100_06930)1429678..1429887+210WP_264676290.1hypothetical protein-
LP100_RS07010 (LP100_06935)1429924..1430124+201WP_264676289.1helix-turn-helix domain-containing protein-
LP100_RS07015 (LP100_06940)1430551..1431255-705WP_264676288.1BRO family protein-
LP100_RS07020 (LP100_06945)1431655..1431837+183WP_264676287.1type II toxin-antitoxin system HicA family toxinToxin
LP100_RS07025 (LP100_06950)1431899..1432312+414WP_264676286.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
LP100_RS07030 (LP100_06955)1432323..1432724-402WP_264676285.1antiterminator Q family protein-
LP100_RS07035 (LP100_06960)1432708..1432929-222WP_264676284.1DUF3310 domain-containing protein-
LP100_RS07040 (LP100_06965)1432926..1433081-156WP_264676283.1hypothetical protein-
LP100_RS07045 (LP100_06970)1433218..1433703-486WP_078273444.1recombination protein NinB-
LP100_RS07050 (LP100_06975)1433767..1434444-678WP_264682991.1Bro-N domain-containing protein-
LP100_RS07055 (LP100_06980)1435106..1435303+198WP_264682993.1ribbon-helix-helix domain-containing protein-
LP100_RS07060 (LP100_06985)1435350..1435628-279WP_264682994.1hypothetical protein-
LP100_RS07065 (LP100_06990)1435625..1436032-408WP_112742083.1VRR-NUC domain-containing protein-
LP100_RS07070 (LP100_06995)1436029..1436637-609WP_264676191.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1399276..145884859572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226142 WP_264676287.1 NZ_CP087784:1431655-1431837 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226142 NZ_CP122315:c4321642-4321307 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226142 WP_264676286.1 NZ_CP087784:1431899-1432312 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226142 NZ_CP122315:c4321890-4321642 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References