Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1431655..1432312 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP100_RS07020 Protein ID WP_264676287.1
Coordinates 1431655..1431837 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP100_RS07025 Protein ID WP_264676286.1
Coordinates 1431899..1432312 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP100_RS06995 (LP100_06920) 1427628..1429025 - 1398 WP_264676292.1 phage terminase large subunit -
LP100_RS07000 (LP100_06925) 1429025..1429564 - 540 WP_264676291.1 terminase small subunit -
LP100_RS07005 (LP100_06930) 1429678..1429887 + 210 WP_264676290.1 hypothetical protein -
LP100_RS07010 (LP100_06935) 1429924..1430124 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP100_RS07015 (LP100_06940) 1430551..1431255 - 705 WP_264676288.1 BRO family protein -
LP100_RS07020 (LP100_06945) 1431655..1431837 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP100_RS07025 (LP100_06950) 1431899..1432312 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP100_RS07030 (LP100_06955) 1432323..1432724 - 402 WP_264676285.1 antiterminator Q family protein -
LP100_RS07035 (LP100_06960) 1432708..1432929 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP100_RS07040 (LP100_06965) 1432926..1433081 - 156 WP_264676283.1 hypothetical protein -
LP100_RS07045 (LP100_06970) 1433218..1433703 - 486 WP_078273444.1 recombination protein NinB -
LP100_RS07050 (LP100_06975) 1433767..1434444 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP100_RS07055 (LP100_06980) 1435106..1435303 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP100_RS07060 (LP100_06985) 1435350..1435628 - 279 WP_264682994.1 hypothetical protein -
LP100_RS07065 (LP100_06990) 1435625..1436032 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP100_RS07070 (LP100_06995) 1436029..1436637 - 609 WP_264676191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1399276..1458848 59572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226142 WP_264676287.1 NZ_CP087784:1431655-1431837 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226142 NZ_CP122315:c4321642-4321307 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226142 WP_264676286.1 NZ_CP087784:1431899-1432312 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226142 NZ_CP122315:c4321890-4321642 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References