Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 670609..671152 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP100_RS03445 Protein ID WP_245952240.1
Coordinates 670925..671152 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP100_RS03440 Protein ID WP_078273964.1
Coordinates 670609..670944 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP100_RS03420 (LP100_03390) 665769..666851 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP100_RS03425 (LP100_03395) 666985..667752 - 768 WP_112742541.1 carbonic anhydrase family protein -
LP100_RS03430 (LP100_03400) 668398..669579 - 1182 WP_078274027.1 fatty acid desaturase -
LP100_RS03435 (LP100_03405) 669841..670425 + 585 Protein_661 TetR/AcrR family transcriptional regulator -
LP100_RS03440 (LP100_03410) 670609..670944 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP100_RS03445 (LP100_03415) 670925..671152 - 228 WP_245952240.1 hypothetical protein Toxin
LP100_RS03450 (LP100_03420) 671384..672091 + 708 WP_264675942.1 ParA family protein -
LP100_RS03455 (LP100_03425) 672181..673566 - 1386 WP_078273966.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8451.18 Da        Isoelectric Point: 4.5519

>T226141 WP_245952240.1 NZ_CP087784:c671152-670925 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Download         Length: 228 bp

>T226141 NZ_CP122315:4188004-4188333 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226141 WP_078273964.1 NZ_CP087784:c670944-670609 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226141 NZ_CP122315:4187666-4187983 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References