Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 438202..438854 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP100_RS02225 Protein ID WP_078275188.1
Coordinates 438462..438854 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP100_RS02220 Protein ID WP_264675982.1
Coordinates 438202..438465 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP100_RS02190 (LP100_02180) 433487..434821 + 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP100_RS02195 (LP100_02185) 434965..435258 + 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP100_RS02200 (LP100_02190) 435251..435523 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP100_RS02205 (LP100_02195) 435588..436043 - 456 WP_264675985.1 type IV secretion protein Rhs -
LP100_RS02210 (LP100_02200) 436128..436505 + 378 WP_264675984.1 hypothetical protein -
LP100_RS02215 (LP100_02205) 436863..438122 + 1260 WP_264675983.1 replication-associated recombination protein A -
LP100_RS02220 (LP100_02210) 438202..438465 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP100_RS02225 (LP100_02215) 438462..438854 + 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP100_RS02230 (LP100_02220) 438977..439507 + 531 WP_078275187.1 HI_0552 family protein -
LP100_RS02235 (LP100_02225) 439504..440070 - 567 WP_078275186.1 hypothetical protein -
LP100_RS02240 (LP100_02230) 440073..440309 - 237 WP_078275185.1 sulfurtransferase TusA -
LP100_RS02245 (LP100_02235) 440306..440764 - 459 WP_078275184.1 acyl-CoA thioesterase -
LP100_RS02250 (LP100_02240) 440844..441866 - 1023 WP_078275183.1 hypothetical protein -
LP100_RS02255 (LP100_02245) 441897..442775 - 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP100_RS02260 (LP100_02250) 442821..443762 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226140 WP_078275188.1 NZ_CP087784:438462-438854 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226140 NZ_CP122315:4176469-4177542 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226140 WP_264675982.1 NZ_CP087784:438202-438465 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226140 NZ_CP122315:4177535-4177906 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References