Detailed information of TA system TA226139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 434965..435523
• Replicon: chromosome
• Accession: NZ_CP087784
• Organism: Moraxella bovis strain SAM57973

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP100_RS02200
• Protein ID: WP_228157760.1
• Coordinates: 435251..435523 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP100_RS02195
• Protein ID: WP_029103533.1
• Coordinates: 434965..435258 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP100_RS02175 (LP100_02165)	430476..431810	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP100_RS02180 (LP100_02170)	431930..432541	+	612	WP_112741794.1	methyltransferase	-
LP100_RS02185 (LP100_02175)	432562..433278	+	717	WP_078275193.1	hypothetical protein	-
LP100_RS02190 (LP100_02180)	433487..434821	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP100_RS02195 (LP100_02185)	434965..435258	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP100_RS02200 (LP100_02190)	435251..435523	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP100_RS02205 (LP100_02195)	435588..436043	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP100_RS02210 (LP100_02200)	436128..436505	+	378	WP_264675984.1	hypothetical protein	-
LP100_RS02215 (LP100_02205)	436863..438122	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP100_RS02220 (LP100_02210)	438202..438465	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP100_RS02225 (LP100_02215)	438462..438854	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP100_RS02230 (LP100_02220)	438977..439507	+	531	WP_078275187.1	HI_0552 family protein	-
LP100_RS02235 (LP100_02225)	439504..440070	-	567	WP_078275186.1	hypothetical protein	-
LP100_RS02240 (LP100_02230)	440073..440309	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226139 WP_228157760.1 NZ_CP087784:435251-435523 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226139 NZ_CP122315:c3500388-3500137 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226139 WP_029103533.1 NZ_CP087784:434965-435258 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226139 NZ_CP122315:c3500140-3499886 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6