Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2102669..2103318 Replicon chromosome
Accession NZ_CP087771
Organism Moraxella bovis strain SAM109244

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP127_RS10630 Protein ID WP_078274052.1
Coordinates 2102669..2103070 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP127_RS10635 Protein ID WP_112741908.1
Coordinates 2103085..2103318 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP127_RS10595 (LP127_10500) 2098325..2098558 + 234 WP_112741910.1 ASCH domain-containing protein -
LP127_RS10600 (LP127_10505) 2098604..2098753 + 150 WP_162860355.1 hypothetical protein -
LP127_RS10605 (LP127_10510) 2098750..2099169 + 420 WP_078274047.1 S4 domain-containing protein -
LP127_RS10615 (LP127_10520) 2099905..2100594 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP127_RS10620 (LP127_10525) 2100693..2101523 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP127_RS10625 (LP127_10530) 2101645..2102145 - 501 WP_112741909.1 WG repeat-containing protein -
LP127_RS10630 (LP127_10535) 2102669..2103070 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP127_RS10635 (LP127_10540) 2103085..2103318 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP127_RS10640 (LP127_10545) 2103366..2105465 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP127_RS10645 (LP127_10550) 2105686..2106279 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP127_RS10650 (LP127_10555) 2106299..2107291 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP127_RS10655 (LP127_10560) 2107473..2107922 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226125 WP_078274052.1 NZ_CP087771:c2103070-2102669 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226125 NZ_CP122315:1842478-1842696 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226125 WP_112741908.1 NZ_CP087771:c2103318-2103085 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226125 NZ_CP122315:1842078-1842452 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References