Detailed information of TA system TA226122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1785077..1785629
• Replicon: chromosome
• Accession: NZ_CP087771
• Organism: Moraxella bovis strain SAM109244

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP127_RS08825
• Protein ID: WP_029102268.1
• Coordinates: 1785077..1785355 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP127_RS08830
• Protein ID: WP_078273473.1
• Coordinates: 1785342..1785629 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP127_RS08795 (LP127_08720)	1781064..1781840	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP127_RS08800 (LP127_08725)	1781952..1782302	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP127_RS08805 (LP127_08730)	1782450..1782965	+	516	WP_115369660.1	hypothetical protein	-
LP127_RS08810 (LP127_08735)	1782958..1783248	+	291	WP_264676229.1	hypothetical protein	-
LP127_RS08815 (LP127_08740)	1783461..1784126	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP127_RS08820 (LP127_08745)	1784326..1784982	+	657	WP_078273472.1	YqiJ family protein	-
LP127_RS08825 (LP127_08750)	1785077..1785355	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP127_RS08830 (LP127_08755)	1785342..1785629	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP127_RS08835 (LP127_08760)	1785639..1787369	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP127_RS08840	1787413..1787538	-	126	WP_264676709.1	hypothetical protein	-
LP127_RS08845 (LP127_08765)	1787567..1789066	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP127_RS08850 (LP127_08770)	1789145..1790194	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226122 WP_029102268.1 NZ_CP087771:1785077-1785355 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226122 NZ_CP122315:1383196-1383537 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226122 WP_078273473.1 NZ_CP087771:1785342-1785629 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226122 NZ_CP122315:c1383201-1383125 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3