Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 500781..501433 Replicon chromosome
Accession NZ_CP087771
Organism Moraxella bovis strain SAM109244

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP127_RS02540 Protein ID WP_078275188.1
Coordinates 501041..501433 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP127_RS02535 Protein ID WP_264675982.1
Coordinates 500781..501044 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP127_RS02505 (LP127_02495) 496066..497400 + 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP127_RS02510 (LP127_02500) 497544..497837 + 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP127_RS02515 (LP127_02505) 497830..498102 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP127_RS02520 (LP127_02510) 498167..498622 - 456 WP_264675985.1 type IV secretion protein Rhs -
LP127_RS02525 (LP127_02515) 498707..499084 + 378 WP_264675984.1 hypothetical protein -
LP127_RS02530 (LP127_02520) 499442..500701 + 1260 WP_264675983.1 replication-associated recombination protein A -
LP127_RS02535 (LP127_02525) 500781..501044 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP127_RS02540 (LP127_02530) 501041..501433 + 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP127_RS02545 (LP127_02535) 501556..502086 + 531 WP_078275187.1 HI_0552 family protein -
LP127_RS02550 (LP127_02540) 502083..502649 - 567 WP_078275186.1 hypothetical protein -
LP127_RS02555 (LP127_02545) 502652..502888 - 237 WP_078275185.1 sulfurtransferase TusA -
LP127_RS02560 (LP127_02550) 502885..503343 - 459 WP_078275184.1 acyl-CoA thioesterase -
LP127_RS02565 (LP127_02555) 503423..504445 - 1023 WP_078275183.1 hypothetical protein -
LP127_RS02570 (LP127_02560) 504476..505354 - 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP127_RS02575 (LP127_02565) 505400..506341 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226119 WP_078275188.1 NZ_CP087771:501041-501433 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226119 NZ_CP122315:c14101-13787 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226119 WP_264675982.1 NZ_CP087771:500781-501044 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226119 NZ_CP122315:c13790-13374 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References