Detailed information of TA system TA226118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 497544..498102
• Replicon: chromosome
• Accession: NZ_CP087771
• Organism: Moraxella bovis strain SAM109244

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP127_RS02515
• Protein ID: WP_228157760.1
• Coordinates: 497830..498102 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP127_RS02510
• Protein ID: WP_029103533.1
• Coordinates: 497544..497837 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP127_RS02490 (LP127_02480)	493055..494389	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP127_RS02495 (LP127_02485)	494509..495120	+	612	WP_112741794.1	methyltransferase	-
LP127_RS02500 (LP127_02490)	495141..495857	+	717	WP_078275193.1	hypothetical protein	-
LP127_RS02505 (LP127_02495)	496066..497400	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP127_RS02510 (LP127_02500)	497544..497837	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP127_RS02515 (LP127_02505)	497830..498102	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP127_RS02520 (LP127_02510)	498167..498622	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP127_RS02525 (LP127_02515)	498707..499084	+	378	WP_264675984.1	hypothetical protein	-
LP127_RS02530 (LP127_02520)	499442..500701	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP127_RS02535 (LP127_02525)	500781..501044	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP127_RS02540 (LP127_02530)	501041..501433	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP127_RS02545 (LP127_02535)	501556..502086	+	531	WP_078275187.1	HI_0552 family protein	-
LP127_RS02550 (LP127_02540)	502083..502649	-	567	WP_078275186.1	hypothetical protein	-
LP127_RS02555 (LP127_02545)	502652..502888	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	katA	440785..500701	59916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226118 WP_228157760.1 NZ_CP087771:497830-498102 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226118 NZ_CP122304:2112705-2113568 [Enterococcus hirae]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226118 WP_029103533.1 NZ_CP087771:497544-497837 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226118 NZ_CP122304:2112431-2112703 [Enterococcus hirae]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6