Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2284935..2285593 Replicon chromosome
Accession NZ_CP087768
Organism Moraxella bovis strain SAM109245

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP116_RS11620 Protein ID WP_078274940.1
Coordinates 2285405..2285593 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP116_RS11615 Protein ID WP_112741846.1
Coordinates 2284935..2285342 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP116_RS11585 (LP116_11480) 2280166..2281995 - 1830 WP_078274936.1 hypothetical protein -
LP116_RS11590 (LP116_11485) 2281983..2282327 - 345 WP_078274937.1 hypothetical protein -
LP116_RS11595 (LP116_11490) 2282328..2283134 - 807 WP_112741850.1 hypothetical protein -
LP116_RS11600 (LP116_11495) 2283188..2283625 - 438 WP_162860346.1 hypothetical protein -
LP116_RS11605 (LP116_11500) 2283559..2283891 - 333 WP_112741848.1 hypothetical protein -
LP116_RS11610 (LP116_11505) 2283888..2284859 - 972 WP_112741847.1 phage tail tape measure protein -
LP116_RS11615 (LP116_11510) 2284935..2285342 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP116_RS11620 (LP116_11515) 2285405..2285593 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP116_RS11625 (LP116_11520) 2285736..2285951 - 216 WP_078274941.1 hypothetical protein -
LP116_RS11630 (LP116_11525) 2285953..2286552 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP116_RS11635 (LP116_11530) 2286659..2286865 - 207 WP_264676102.1 DNA-binding protein -
LP116_RS11640 (LP116_11535) 2286988..2287332 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP116_RS11645 (LP116_11540) 2287376..2288128 - 753 WP_078274945.1 hypothetical protein -
LP116_RS11650 (LP116_11545) 2288206..2288406 - 201 WP_264676324.1 hypothetical protein -
LP116_RS11655 (LP116_11550) 2288415..2288606 - 192 WP_264676101.1 DNA-binding protein -
LP116_RS11660 (LP116_11555) 2288621..2288830 - 210 WP_078274960.1 hypothetical protein -
LP116_RS11665 (LP116_11560) 2288995..2289294 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP116_RS11670 (LP116_11565) 2289489..2289776 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP116_RS11675 (LP116_11570) 2289773..2290192 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2275698..2290192 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226116 WP_078274940.1 NZ_CP087768:c2285593-2285405 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226116 NZ_CP122301:4490194-4490505 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226116 WP_112741846.1 NZ_CP087768:c2285342-2284935 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226116 NZ_CP122301:4490502-4490948 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References