Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2124510..2125159 Replicon chromosome
Accession NZ_CP087768
Organism Moraxella bovis strain SAM109245

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP116_RS10810 Protein ID WP_078274052.1
Coordinates 2124510..2124911 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP116_RS10815 Protein ID WP_112741908.1
Coordinates 2124926..2125159 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP116_RS10775 (LP116_10670) 2120166..2120399 + 234 WP_112741910.1 ASCH domain-containing protein -
LP116_RS10780 (LP116_10675) 2120418..2120594 + 177 WP_228157829.1 ASCH domain-containing protein -
LP116_RS10785 (LP116_10680) 2120591..2121010 + 420 WP_078274047.1 S4 domain-containing protein -
LP116_RS10795 (LP116_10690) 2121746..2122435 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP116_RS10800 (LP116_10695) 2122534..2123364 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP116_RS10805 (LP116_10700) 2123486..2123986 - 501 WP_264684084.1 WG repeat-containing protein -
LP116_RS10810 (LP116_10705) 2124510..2124911 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP116_RS10815 (LP116_10710) 2124926..2125159 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP116_RS10820 (LP116_10715) 2125207..2127306 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP116_RS10825 (LP116_10720) 2127527..2128120 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP116_RS10830 (LP116_10725) 2128140..2129132 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP116_RS10835 (LP116_10730) 2129314..2129763 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226115 WP_078274052.1 NZ_CP087768:c2124911-2124510 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226115 NZ_CP122301:c4488961-4488650 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226115 WP_112741908.1 NZ_CP087768:c2125159-2124926 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226115 NZ_CP122301:c4488649-4488359 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References