Detailed information of TA system TA226114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2019833..2020410
• Replicon: chromosome
• Accession: NZ_CP087768
• Organism: Moraxella bovis strain SAM109245

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP116_RS10180
• Protein ID: WP_078275234.1
• Coordinates: 2019833..2020168 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP116_RS10185
• Protein ID: WP_078275235.1
• Coordinates: 2020168..2020410 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP116_RS10155 (LP116_10060)	2015173..2015373	+	201	WP_112741955.1	hypothetical protein	-
LP116_RS10160 (LP116_10065)	2015533..2016117	+	585	WP_112741954.1	hypothetical protein	-
LP116_RS10165 (LP116_10070)	2016282..2018426	+	2145	WP_264684081.1	cation-translocating P-type ATPase	-
LP116_RS10170 (LP116_10075)	2018516..2018704	-	189	WP_143821748.1	hypothetical protein	-
LP116_RS10175 (LP116_10080)	2018776..2019771	-	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP116_RS10180 (LP116_10085)	2019833..2020168	-	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP116_RS10185 (LP116_10090)	2020168..2020410	-	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP116_RS10190 (LP116_10095)	2020617..2021696	+	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP116_RS10195 (LP116_10100)	2022078..2022800	-	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP116_RS10200 (LP116_10105)	2022989..2023615	+	627	WP_078275237.1	septation protein IspZ	-
LP116_RS10205 (LP116_10110)	2023775..2024080	+	306	WP_078275238.1	YciI family protein	-
LP116_RS10210 (LP116_10115)	2024089..2024511	+	423	WP_078275239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226114 WP_078275234.1 NZ_CP087768:c2020168-2019833 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226114 NZ_CP122301:c4179725-4179234 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226114 WP_078275235.1 NZ_CP087768:c2020410-2020168 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226114 NZ_CP122301:c4180015-4179722 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA