Detailed information of TA system TA226112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1798356..1798908
• Replicon: chromosome
• Accession: NZ_CP087768
• Organism: Moraxella bovis strain SAM109245

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP116_RS08940
• Protein ID: WP_029102268.1
• Coordinates: 1798356..1798634 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP116_RS08945
• Protein ID: WP_078273473.1
• Coordinates: 1798621..1798908 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP116_RS08910 (LP116_08825)	1794343..1795119	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP116_RS08915 (LP116_08830)	1795231..1795581	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP116_RS08920 (LP116_08835)	1795729..1796244	+	516	WP_115369660.1	hypothetical protein	-
LP116_RS08925 (LP116_08840)	1796237..1796527	+	291	WP_264676229.1	hypothetical protein	-
LP116_RS08930 (LP116_08845)	1796740..1797405	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP116_RS08935 (LP116_08850)	1797605..1798261	+	657	WP_078273472.1	YqiJ family protein	-
LP116_RS08940 (LP116_08855)	1798356..1798634	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP116_RS08945 (LP116_08860)	1798621..1798908	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP116_RS08950 (LP116_08865)	1798918..1800648	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP116_RS08955	1800692..1800817	-	126	WP_264676709.1	hypothetical protein	-
LP116_RS08960 (LP116_08870)	1800846..1802345	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP116_RS08965 (LP116_08875)	1802424..1803473	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226112 WP_029102268.1 NZ_CP087768:1798356-1798634 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226112 NZ_CP122301:c4031521-4031213 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226112 WP_078273473.1 NZ_CP087768:1798621-1798908 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226112 NZ_CP122301:c4031763-4031524 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3