Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 746516..747092 Replicon chromosome
Accession NZ_CP087768
Organism Moraxella bovis strain SAM109245

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP116_RS03870 Protein ID WP_264676341.1
Coordinates 746832..747092 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP116_RS03865 Protein ID WP_078273964.1
Coordinates 746516..746851 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP116_RS03845 (LP116_03815) 741676..742758 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP116_RS03850 (LP116_03820) 742892..743659 - 768 WP_112742541.1 carbonic anhydrase family protein -
LP116_RS03855 (LP116_03825) 744305..745486 - 1182 WP_078274027.1 fatty acid desaturase -
LP116_RS03860 (LP116_03830) 745748..746332 + 585 Protein_745 TetR/AcrR family transcriptional regulator -
LP116_RS03865 (LP116_03835) 746516..746851 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP116_RS03870 (LP116_03840) 746832..747092 - 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP116_RS03875 (LP116_03845) 747291..747998 + 708 WP_264675942.1 ParA family protein -
LP116_RS03880 (LP116_03850) 748088..749473 - 1386 WP_078273966.1 APC family permease -
LP116_RS03885 (LP116_03855) 749986..752061 - 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226110 WP_264676341.1 NZ_CP087768:c747092-746832 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226110 NZ_CP122301:3602192-3602449 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226110 WP_078273964.1 NZ_CP087768:c746851-746516 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226110 NZ_CP122301:c3602367-3602035 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References