Detailed information of TA system TA226109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 508007..508659
• Replicon: chromosome
• Accession: NZ_CP087768
• Organism: Moraxella bovis strain SAM109245

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP116_RS02615
• Protein ID: WP_078275188.1
• Coordinates: 508267..508659 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP116_RS02610
• Protein ID: WP_264675982.1
• Coordinates: 508007..508270 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP116_RS02580 (LP116_02565)	503292..504626	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP116_RS02585 (LP116_02570)	504770..505063	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP116_RS02590 (LP116_02575)	505056..505328	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP116_RS02595 (LP116_02580)	505393..505848	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP116_RS02600 (LP116_02585)	505933..506310	+	378	WP_264675984.1	hypothetical protein	-
LP116_RS02605 (LP116_02590)	506668..507927	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP116_RS02610 (LP116_02595)	508007..508270	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP116_RS02615 (LP116_02600)	508267..508659	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP116_RS02620 (LP116_02605)	508782..509312	+	531	WP_078275187.1	HI_0552 family protein	-
LP116_RS02625 (LP116_02610)	509309..509875	-	567	WP_078275186.1	hypothetical protein	-
LP116_RS02630 (LP116_02615)	509878..510114	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP116_RS02635 (LP116_02620)	510111..510569	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP116_RS02640 (LP116_02625)	510649..511671	-	1023	WP_078275183.1	hypothetical protein	-
LP116_RS02645 (LP116_02630)	511702..512580	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP116_RS02650 (LP116_02635)	512626..513567	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226109 WP_078275188.1 NZ_CP087768:508267-508659 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226109 NZ_CP122301:3411834-3412052 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226109 WP_264675982.1 NZ_CP087768:508007-508270 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226109 NZ_CP122301:3411432-3411806 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA