Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2603769..2604427 Replicon chromosome
Accession NZ_CP087765
Organism Moraxella bovis strain SAM109246

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP096_RS13345 Protein ID WP_078274940.1
Coordinates 2603769..2603957 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP096_RS13350 Protein ID WP_112741846.1
Coordinates 2604020..2604427 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP096_RS13290 (LP096_13155) 2599170..2599589 - 420 WP_112741841.1 S24 family peptidase -
LP096_RS13295 (LP096_13160) 2599586..2599873 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP096_RS13300 (LP096_13165) 2600068..2600367 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP096_RS13305 (LP096_13170) 2600532..2600741 + 210 WP_078274960.1 hypothetical protein -
LP096_RS13310 (LP096_13175) 2600756..2600947 + 192 WP_264676101.1 DNA-binding protein -
LP096_RS13315 (LP096_13180) 2600956..2601156 + 201 WP_264676324.1 hypothetical protein -
LP096_RS13320 (LP096_13185) 2601234..2601986 + 753 WP_078274945.1 hypothetical protein -
LP096_RS13325 (LP096_13190) 2602030..2602374 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP096_RS13330 (LP096_13195) 2602497..2602703 + 207 WP_264676102.1 DNA-binding protein -
LP096_RS13335 (LP096_13200) 2602810..2603409 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP096_RS13340 (LP096_13205) 2603411..2603626 + 216 WP_078274941.1 hypothetical protein -
LP096_RS13345 (LP096_13210) 2603769..2603957 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP096_RS13350 (LP096_13215) 2604020..2604427 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP096_RS13355 (LP096_13220) 2604503..2605474 + 972 WP_112741847.1 phage tail tape measure protein -
LP096_RS13360 (LP096_13225) 2605471..2605803 + 333 WP_112741848.1 hypothetical protein -
LP096_RS13365 (LP096_13230) 2605737..2606174 + 438 WP_162860346.1 hypothetical protein -
LP096_RS13370 (LP096_13235) 2606228..2607034 + 807 WP_112741850.1 hypothetical protein -
LP096_RS13375 (LP096_13240) 2607035..2607379 + 345 WP_078274937.1 hypothetical protein -
LP096_RS13380 (LP096_13245) 2607367..2609196 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2599170..2613665 14495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226106 WP_078274940.1 NZ_CP087765:2603769-2603957 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226106 NZ_CP122301:c989032-988505 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226106 WP_112741846.1 NZ_CP087765:2604020-2604427 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226106 NZ_CP122301:c989319-989029 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References