Detailed information of TA system TA226104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1690523..1691081
• Replicon: chromosome
• Accession: NZ_CP087765
• Organism: Moraxella bovis strain SAM109246

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP096_RS08645
• Protein ID: WP_228157760.1
• Coordinates: 1690523..1690795 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP096_RS08650
• Protein ID: WP_029103533.1
• Coordinates: 1690788..1691081 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP096_RS08605 (LP096_08485)	1685737..1685973	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP096_RS08610 (LP096_08490)	1685976..1686542	+	567	WP_078275186.1	hypothetical protein	-
LP096_RS08615 (LP096_08495)	1686539..1687069	-	531	WP_078275187.1	HI_0552 family protein	-
LP096_RS08620 (LP096_08500)	1687192..1687584	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP096_RS08625 (LP096_08505)	1687581..1687844	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP096_RS08630 (LP096_08510)	1687924..1689183	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP096_RS08635 (LP096_08515)	1689541..1689918	-	378	WP_264675984.1	hypothetical protein	-
LP096_RS08640 (LP096_08520)	1690003..1690458	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP096_RS08645 (LP096_08525)	1690523..1690795	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP096_RS08650 (LP096_08530)	1690788..1691081	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP096_RS08655 (LP096_08535)	1691225..1692559	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP096_RS08660 (LP096_08540)	1692768..1693484	-	717	WP_078275193.1	hypothetical protein	-
LP096_RS08665 (LP096_08545)	1693505..1694116	-	612	WP_112741794.1	methyltransferase	-
LP096_RS08670 (LP096_08550)	1694236..1695570	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226104 WP_228157760.1 NZ_CP087765:c1690795-1690523 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226104 NZ_CP122301:825265-825678 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226104 WP_029103533.1 NZ_CP087765:c1691081-1690788 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226104 NZ_CP122301:825018-825284 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6